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首页> 外文期刊>Journal of Infectious Diseases >Interleukin-12p70 Deficiency Increases Survival and Diminishes Pathology in Trypanosoma congolense Infection
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Interleukin-12p70 Deficiency Increases Survival and Diminishes Pathology in Trypanosoma congolense Infection

机译：白细胞介素12p70缺乏症可增加锥虫锥虫感染的存活率并减少病理。

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摘要

To determine the immunological role played by interleukin (IL)-12 family members in Trypanosoma congolense infection, IL-12p35-/-, IL-12p40-/-, and IL-12p35-/-/p40-/- mice were used. While the latter 2 strains lack all IL-12 homologues, IL-12p35-/- mice still produce IL-12p80 homodimers and IL-23. Compared with wild-type mice, all infected IL-12-deficient mouse strains showed prolonged survival, whereas parasitemia levels were unaltered. Interferon (IFN)-γ production in IL-12-deficient mice was strikingly reduced during the acute and chronic stages of infection, coinciding with significantly reduced chronic-stage hepatocellular damage, as demonstrated by histological analysis and plasma aspartate transaminase measurements. In contrast, IL-10 production was not affected by the absence of IL-12. Taken together, these results show that, during T. congolense infection, the absence of IL-12, but not the IL-12p80 homodimer or IL-23, leads to a reduction in IFN-γ production, which reduces hepatic pathology and improves host survival in conjunction with IL-10 without negatively affecting parasitemia control.
机译：为了确定白介素（IL）-12家族成员在锥虫锥虫感染，IL-12p35 -/-，IL-12p40 -/-和IL中的免疫学作用使用了-12p35 -/- / p40 -/-小鼠。尽管后两个品系缺乏所有IL-12同源物，但IL-12p35 -/-小鼠仍产生IL-12p80同型二聚体和IL-23。与野生型小鼠相比，所有感染IL-12缺陷的小鼠品系均显示出延长的生存期，而寄生虫血症水平未改变。组织学分析和血浆天冬氨酸转氨酶测定结果表明，IL-12缺陷型小鼠在急性和慢性感染期间干扰素（IFN）-γ的产生显着降低，同时慢性肝细胞的慢性损伤也明显减少。相反，IL-10的存在不受IL-12的影响。综上所述，这些结果表明，在弓形虫感染期间，IL-12（而不是IL-12p80同型二聚体或IL-23）的缺失会导致IFN-γ的产生减少，从而降低肝脏的病理状况并改善宿主与IL-10联合生存，不会对寄生虫血症的控制产生负面影响。

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  • 来源
    《Journal of Infectious Diseases》 |2008年第9期|p.1284-1291|共8页
  • 作者

    Mark Barkhuizen1 Stefen Magez12 Bernard Ryffel3 and Frank Brombacher1;

  • 作者单位

    1 Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa 2 Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Recognition, Flanders Interuniversity for Biotechnology, Vrije Universiteit Brussels, Brussels, Belgium 3 Université d'Orléans, Centre National de la Recherche Scienfitifue, Molecular Immunology and Embryology, Orléans, France;

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