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Maternal Neutralizing Antibody and Transmission of Hepatitis C Virus to Infants

机译：母体中和抗体和丙型肝炎病毒向婴儿的传播

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摘要

To determine whether lower levels of hepatitis C virus (HCV)-specific neutralizing antibodies (nAb) are associated with an increased risk of mother-to-child transmission (MTCT) of HCV, HCV nAb titers were assessed in 63 mothers coinfected with HCV and human immunodeficiency virus (HIV) type 1. Of the mothers, 16 transmitted HCV to their infant, but no difference was detected between the ability of maternal plasma from transmitters and nontransmitters to neutralize heterologous HCV pseudoparticles (median nAb titer, 1:125 vs. 1:100; P = .23). In the setting of HIV/HCV coinfection, we found no evidence that HCV nAbs are associated with the prevention of MTCT of HCV.
机译：为了确定丙型肝炎病毒（HCV）特异性中和抗体（nAb）的降低是否与HCV母婴传播（MTCT）的风险增加有关，对63例合并感染HCV和HCV的母亲进行了HCV nAb效价评估。 1型人类免疫缺陷病毒（HIV）。在母亲中，有16例将HCV传播给婴儿，但从传播者和非传播者获得的母体血浆中和异源HCV假颗粒的能力均未发现差异（nAb滴度中位数为1：125vs。 1：100； P = 0.23）。在HIV / HCV合并感染的情况下，我们没有发现HCV nAb与预防HCV MTCT相关的证据。

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  • 来源
    《Journal of Infectious Diseases》 |2008年第11期|p.1651-1655|共5页
  • 作者

    Kimberly A. Dowd1 Ronald C. Hershow5 Sigal Yawetz6 Philip LaRussa7 Clemente Diaz9 Sheldon H. Landesman8 Mary E. Paul10 Jennifer S. Read4 Ming Lu3 David L. Thomas12 Dale M. Netski1 and Stuart C. Ray1;

  • 作者单位

    1Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 2Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 3Department of Clinical Trials and Surveys, Baltimore, Maryland 4Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 5University of Illinois at Chicago School of Public Health, Chicago 6Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 7College of Physicians and Surgeons, Columbia University, New York, New York 8Department of Medicine, Brookdale Hospital, Brooklyn, New York;

    9University of Puerto;

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