Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

Tanja B. Jensen1 Judith M. Gottwein1 Troels K. H. Scheel13 Anne M. Hoegh2 Jesper Eugen-Olsen1 and Jens Bukh134

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Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

机译：高效的基于JFH1的丙型肝炎病毒基因型5a细胞培养系统：同源中和抗体治疗无法控制感染

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Background. Recently, a hepatitis C virus (HCV) cell-culture system was developed that employed strain JFH1 (genotype 2a), and JFH1-based intra- and intergenotypic recombinants now permit functional studies of the structural genes (Core, E1, and E2), p7, and NS2 of genotypes 1–4. The goal was to adapt the system to employ genotype 5.

机译：背景。最近，开发了一种使用菌株JFH1（基因型2a）的丙型肝炎病毒（HCV）细胞培养系统，基于JFH1的基因型和基因型之间的重组体现在可以对结构基因（Core，E1和E2）进行功能研究， p7和基因型1-4的NS2。目的是使系统适应基因型5。

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《Journal of Infectious Diseases》 |2008年第12期|p.1756-1765|共10页
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Tanja B. Jensen1 Judith M. Gottwein1 Troels K. H. Scheel13 Anne M. Hoegh2 Jesper Eugen-Olsen1 and Jens Bukh134;
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1Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Copenhagen University Hospital, Hvidovre 2Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre 3Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark 4Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;

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1. Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection. [J] . Jensen TB, Gottwein JM, Scheel TK, The Journal of Infectious Diseases . 2008,第12期

机译：用于丙型肝炎病毒基因型5a的基于JFH1的高效细胞培养系统：同源中和抗体治疗无法控制感染。
2. Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization [J] . Troels K. H. Scheel, Judith M. Gottwein, Tanja B. Jensen, Proceedings of the National Academy of Sciences of the United States of America . 2008,第3期

机译：基于JFH1的丙型肝炎病毒基因型4a细胞培养系统的开发和交叉基因型中和的证据
3. Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors [J] . RamirezS., LiY.-P., JensenS.B., Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2014,第2期

机译：三种丙型肝炎病毒基因型2b菌株的高效感染细胞培养及其对铅蛋白酶，非结构蛋白5A和聚合酶抑制剂的敏感性
4. Influence of hepatitis C virus genotypes and F protein on outcome of HCV infection among injection drug users [C] . Yun Zhang, Jingjing Yang, Haopeng Wang, International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：丙型肝炎病毒基因型和F蛋白对注射吸毒者HCV感染结局的影响
5. A serosurvey of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus infection among inmates entering the California correctional system. [D] . Ruiz, Juan Domingo. 1997

机译：对进入加利福尼亚教养系统的囚犯进行的人类免疫缺陷病毒，乙型肝炎病毒和丙型肝炎病毒感染的血清调查。
6. Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant [O] . Christian K. Mathiesen, Jannick Prentoe, Luke W. Meredith, 2015

机译：自适应突变增强了高滴度丙型肝炎病毒基因型5a核心NS2 JFH1为基础的重组的组装和细胞间传递。
7. Highly Efficient JFH1‐Based Cell‐Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing‐Antibody Treatment to Control Infection [O] . Tanja B. Jensen, Judith M. Gottwein, Troels K. H. Scheel, 2008

机译：高效的JFH1基细胞培养系统用于丙型肝炎病毒基因型5A：同源中和抗体治疗对照感染的同源中和 - 抗体治疗

Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

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