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首页> 外文期刊>Japanese journal of applied physics >Selective removal of atherosclerotic plaque with a quantum cascade laser in the 5.7 mu m wavelength range
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Selective removal of atherosclerotic plaque with a quantum cascade laser in the 5.7 mu m wavelength range

机译：用波长为5.7μm的量子级联激光选择性去除动脉粥样硬化斑块

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摘要

Atherosclerotic plaques consist mainly of cholesteryl esters, and the C=O stretching vibration mode of cholesteryl esters strongly absorbs radiation at a wavelength of 5.75 mu m. For clinical application of less-invasive laser angioplasty with 5.75 mu m, a compact laser is required. Quantum cascade lasers (QCLs) are semiconductor lasers that can emit radiation in the mid-IR range. In this study, the potential of the QCL for less-invasive laser angioplasty was evaluated. At the average power density of 180W/cm(2), the atherosclerotic aorta was ablated for the irradiation time of 1 s or more, whereas the normal aorta was ablated for more than 10 s. This demonstrates that selective ablation of the atherosclerotic aorta was achieved. However, strong coagulation and carbonization were observed. For reducing thermal effects, improving the pulse structure is required. In conclusion, the QCL achieved the selective ablation of the atherosclerotic lesions, which indicates the potential of the QCL. (C) 2015 The Japan Society of Applied Physics
机译：动脉粥样硬化斑块主要由胆固醇酯组成，胆固醇酯的C ＝ O拉伸振动模式强烈吸收5.75μm波长的辐射。对于5.75微米的微创激光血管成形术的临床应用，需要紧凑型激光。量子级联激光器（QCL）是可以发射中红外范围辐射的半导体激光器。在这项研究中，评估了QCL在微创激光血管成形术中的潜力。在平均功率密度为180W / cm（2）的情况下，在1 s或更长的照射时间内消融动脉粥样硬化主动脉，而在正常的主动脉上消融10 s以上。这表明实现了动脉粥样硬化主动脉的选择性消融。然而，观察到强烈的凝结和碳化。为了减少热效应，需要改善脉冲结构。总之，QCL实现了动脉粥样硬化病变的选择性消融，这表明了QCL的潜力。 （C）2015年日本应用物理学会

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  • 来源
    《Japanese journal of applied physics》 |2015年第11期|112701.1-112701.6|共6页
  • 作者

    Hashimura Keisuke; Ishii Katsunori; Awazu Kunio;

  • 作者单位

    Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan|Japan Soc Promot Sci, Chiyoda Ku, Tokyo 1020083, Japan;

    Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan;

    Osaka Univ, Grad Sch Engn, Suita, Osaka 5650871, Japan|Osaka Univ, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan|Osaka Univ, Global Ctr Med Engn & Informat, Suita, Osaka 5650871, Japan;

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