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首页> 外文期刊>Japanese journal of applied physics >Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering
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Graphene oxide coating facilitates the bioactivity of scaffold material for tissue engineering

机译：氧化石墨烯涂层促进组织工程支架材料的生物活性

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摘要

Carbon-based nanomaterials are being investigated for biomedical applications. Graphene oxide (GO), a monolayer of carbon, holds promise as a tissue engineering substrate due to its unique physicochemical properties. The aim of this study was to evaluate the effect of a GO coating on cell proliferation and differentiation in vitro. We also assessed the bioactivities of collagen scaffolds coated with different concentrations of GO in rats. The results showed that GO affects both cell proliferation and differentiation, and improves the properties of collagen scaffolds. Subcutaneous implant tests showed that low concentrations of GO scaffold enhances cell in-growth and is highly biodegradable, whereas high concentrations of GO coating resulted in adverse biological effects. Consequently, scaffolds modified with a suitable concentration of GO are useful as a bioactive material for tissue engineering.
机译：碳基纳米材料正在研究用于生物医学应用。氧化石墨烯（GO）是单层碳，由于其独特的物理化学特性，有望作为组织工程基质。这项研究的目的是评估GO涂层对体外细胞增殖和分化的影响。我们还评估了在大鼠中涂有不同浓度GO的胶原蛋白支架的生物活性。结果表明，GO影响细胞增殖和分化，并改善胶原蛋白支架的性质。皮下植入物测试表明，低浓度的GO支架可促进细胞向内生长，并且具有很高的生物降解性，而高浓度的GO涂层会导致不利的生物学影响。因此，用适当浓度的GO修饰的支架可用作用于组织工程的生物活性材料。

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  • 来源
    《Japanese journal of applied physics》 |2014年第6s期|06JD04.1-06JD04.7|共7页
  • 作者

    Erika Nishida; Hirofumi Miyaji; Hiroko Takita; Izumi Kanayama; Maiko Tsuji; Tsukasa Akasaka; Tsutomu Sugaya; Ryuji Sakagami; Masamitsu Kawanami;

  • 作者单位

    Department of Periodontology and Endodontology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Department of Periodontology and Endodontology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Support Section for Education and Research, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Department of Periodontology and Endodontology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Mitsubishi Gas Chemical Co., Inc., Katsushika, Tokyo 125-8601, Japan;

    Department of Biomedical, Dental Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Department of Periodontology and Endodontology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

    Section of Periodontology, Department of Odontology, Fukuoka Dental College, Fukuoka 814-0193, Japan;

    Department of Periodontology and Endodontology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan;

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