α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

Toshifumi Miyazawa Eiichi Ensatsu Makoto Hiramatsu Ryoji Yanagihara and Takashi Yamada

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α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

机译：通过氨基甲酸甲酯作为有机介质中的酰基供体，通过动力学控制的方法进行α-胰蛋白酶催化的片段缩合

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The superiority of the carbamoylmethyl ester as an acyl donor for the α-chymotrypsin-catalysed segmentncondensations via the kinetically controlled approach is demonstrated in several model systems carried out innorganic media with low water content. Furthermore, this approach is successfully applied to the construction ofnthe Leu-enkephalin sequence via a 4 u0001 1 segment coupling.

机译：氨基甲酸酯甲酯作为酰基供体通过动力学控制的方法在α-胰凝乳蛋白酶催化的链段缩合反应中的优越性已在几种低水无机介质模型系统中得到证实。此外，该方法通过4 u0001 1段偶联成功地应用于亮-脑啡肽序列的构建。

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《Journal of the Chemical Society, Perkin Transactions 1》 |2002年第3期|p.396-401|共6页
作者
Toshifumi Miyazawa Eiichi Ensatsu Makoto Hiramatsu Ryoji Yanagihara and Takashi Yamada;
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Department of Chemistry, Faculty of Science and Engineering, Konan University,Higashinada-ku, Kobe 658-8501, Japan;

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1. alpha-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media [J] . Miyazawa T., Ensatsu E., Hiramatsu M., Journal of the Chemical Society, Perkin Transactions 1 . 2002,第3期

机译：通过氨基甲酸甲酯作为有机介质中的酰基供体的动力学控制方法，α-胰蛋白酶催化的链段缩合反应
2. Superiority of the carbamoylmethyl ester as an acyl donor for the protease-catalyzed kinetically controlled peptide synthesis in organic media: Application to segment condensations [J] . Miyazawa T., Tanaka K., Yanagihara R., Chemistry Letters . 1999,第10期

机译：氨基甲酰基甲基酯作为酰基供体在有机介质中蛋白酶催化的动力学控制肽合成中的优越性：在片段缩合中的应用
3. α-Chymotrypsin-catalysed peptide synthesis via the kinetically controlled approach using activated esters as acyl donors in organic solvents with low water content: incorporation of non-protein amino acids into peptides [J] . Toshifumi Miyazawa Shin’ichi Nakajo Miyako Nishikawa Kazumi Hamahara Kiwamu Imagawa Eiichi Ensatsu Ryoji Yanagihara and Takashi Yamada Journal of the Chemical Society, Perkin Transactions 1 . 2001,第1期

机译：在含水量低的有机溶剂中使用活化的酯作为酰基供体，通过动力学控制的方法合成α-胰蛋白酶催化的肽：将非蛋白质氨基酸掺入肽中
4. PROTEASE-CATALYZED SEGMENT CONDENSATIONS USING CARBAMOYLMETHYL ESTERS AS ACYL DONORS [C] . Toshifumi Miyazawa, Takao Horimoto, Takashi Murashima the European Peptide Symposium . 2007

机译：使用氨基甲酰基酯作为酰基供体的蛋白酶催化的区段缩聚
5. Evaluation of kinetic controls on microbially-mediated reactions in an electron donor-limited environment. [D] . Driver, Erin M. 2012

机译：电子供体受限环境中微生物介导反应动力学控制的评价。
6. Donor–acceptor-stabilised germanium analogues of acid chloride ester and acyl pyrrole compounds: synthesis and reactivity [O] . Mahendra Kumar Sharma, Soumen Sinhababu, Pritam Mahawar, 2019

机译：供体-受体稳定的酰氯酯和酰基吡咯化合物的锗类似物：合成和反应性
7. Different kinetic patterns in the α-chymotrypsin-catalysed hydrolysis of synthetic ester substrates [O] . Garrell Joan, M. Cuchillo Claudi 1985

机译：α-胰凝乳蛋白酶催化的合成酯底物水解中的不同动力学模式

α-Chymotrypsin-catalysed segment condensations via the kinetically controlled approach using carbamoylmethyl esters as acyl donors in organic media

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