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首页> 外文期刊>Journal of Analytical Atomic Spectrometry >Nano-particle analysis using dwell times between 10 μs and 70 μs with an upper counting limit of greater than 3 × 10~7 cps and a gold nanoparticle detection limit of less than 10 nm diameter
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Nano-particle analysis using dwell times between 10 μs and 70 μs with an upper counting limit of greater than 3 × 10~7 cps and a gold nanoparticle detection limit of less than 10 nm diameter

机译：停留时间在10μs至70μs之间的纳米颗粒分析，计数上限大于3×10〜7 cps，金纳米颗粒检测限小于10 nm直径

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Inductively coupled plasma mass spectrometry (ICP-MS) is proving to be a useful tool for characterization and quantification of metallic nanoparticles. However, the short (200-400 μs) transient signals generated by single particle events have to date presented challenges to current instrumentation and methodologies. Minimum dwell times are available commercially at 50-100 μs timings but limitations in sensitivity for quadrupole ICP-MS make analysis of particles below 10 nm diameter difficult. A further limitation of ICP-MS when using smaller dwell times is the available dynamic range. Typically, a simultaneous detector as used with most ICP-MS has a maximum count ceiling of ～3 × 10~6 cps which equates to only 150 counts for a 50 μs dwell. This work will present data acquired on a magnetic sector ICP-MS with GHz ppm~(-1) sensitivities using dwell times down to 10 μs and requiring no hardware modifications. This work will demonstrate the advantages obtained with the ability to measure fast transient signals with count rates in excess of 3 × 10~7 cps. A further range extension facility based on physical attenuation of the ion beam will be demonstrated which allows the same faster dwell times to be used for signals in excess of 1 × 10~9 cps. A novel data processing technique will be described, which overcomes the shortcomings of previous techniques when fixed particle signal widths and compliance with ideal Poisson statistics for error correction have been assumed. Data will be presented to show the non-ideal behaviour of ion cloud signals from nano-particles and the measurable impact of these behaviours on the calculations.
机译：电感耦合等离子体质谱（ICP-MS）被证明是表征和定量金属纳米颗粒的有用工具。然而，迄今为止，由单粒子事件产生的短时间（200-400μs）瞬态信号对当前的仪器和方法提出了挑战。最小停留时间可在商业上以50-100μs的时间获得，但是四极杆ICP-MS的灵敏度限制使得难以分析直径10 nm以下的颗粒。使用更短的驻留时间时，ICP-MS的另一个局限性是可用的动态范围。通常，大多数ICP-MS所用的同时检测器的最大计数上限为〜3×10〜6 cps，对于50μs的停留时间仅相当于150个计数。这项工作将展示在磁性扇区ICP-MS上以GHz ppm〜（-1）灵敏度获得的数据，使用的停留时间低至10μs，并且无需修改硬件。这项工作将证明在测量计数速率超过3×10〜7 cps的快速瞬态信号时所具有的优势。将展示基于离子束物理衰减的进一步范围扩展功能，该功能允许将相同的更快的驻留时间用于超过1×10〜9 cps的信号。将描述一种新颖的数据处理技术，该技术将克服以前的技术的缺点，前提是已经假定了固定的粒子信号宽度和符合用于纠错的理想Poisson统计量。将提供数据以显示来自纳米粒子的离子云信号的非理想行为以及这些行为对计算的可测量影响。

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  • 来源
    《Journal of Analytical Atomic Spectrometry》 |2016年第6期|1234-1242|共9页
  • 作者

    P. Shaw; A. Donard;

  • 作者单位

    Nu Instruments, 74 Clywedog Road South, Wrexham, UK, LL13 9XS;

    Nu Instruments, 74 Clywedog Road South, Wrexham, UK, LL13 9XS;

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