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首页> 外文期刊>Journal of applied measurement >A Rasch Analysis for Classification of Systemic Lupus Erythematosus and Mixed Connective Tissue Disease
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A Rasch Analysis for Classification of Systemic Lupus Erythematosus and Mixed Connective Tissue Disease

机译：Rasch分析系统性红斑狼疮和混合性结缔组织病的分类

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摘要

The classification of rheumatic diseases is challenging because these diseases have protean and frequently overlapping clinical and laboratory manifestations. This problem is typified by the difficulty of classification and differentiation of two prototypic multi-system autoimmune diseases, Systemic Lupus Erythematosus (SLE) and Mixed Connective Tissue Disease (MCTD). The researchers submitted medical risk factor data represented by instrument or laboratory measures and physician judgments (12 key features for SLE) from 43 patients diagnosed with SLE and 12 key features for MCTD from 51 patients diagnosed with MCTD to the WINSTEPS Rasch analysis program. Using Rasch model parameterization, and fit and residuals analyses, the researchers identified separate dimensions for MCTD and SLE, thereby lending support to the position that MCTD is its own separate disease, distinct from SLE.
机译：风湿性疾病的分类具有挑战性，因为这些疾病具有蛋白质，并且临床和实验室表现经常重叠。这个问题的典型特征是难以分类和区分两种原型多系统自身免疫疾病，即系统性红斑狼疮（SLE）和混合性结缔组织病（MCTD）。研究人员向WINSTEPS Rasch分析程序提交了以仪器或实验室测量以及医师判断（SLE的12个关键特征）为代表的43位被诊断为SLE的患者和MCTD的12个关键特征为51位被诊断为MCTD的患者所代表的医学风险因素数据。研究人员使用Rasch模型参数化以及拟合和残差分析，确定了MCTD和SLE的单独尺寸，从而为MCTD是其自身的独立疾病（不同于SLE）提供了支持。

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