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首页> 外文期刊>Journal of Applied Physics >Theoretical modeling of a thermal wave technique to determine the extent of the freezing region surrounding a cryoprobe
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Theoretical modeling of a thermal wave technique to determine the extent of the freezing region surrounding a cryoprobe

机译：热波技术的理论建模，以确定冷冻探针周围冻结区域的程度

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摘要

Cryosurgery is a clinical technique to ablate undesirable tissues by extreme freezing, exhibiting the merits of minimal invasion, fast recovery, and low cost. A low temperature cryoprobe is used to form a freezing region around the target tissue. Monitoring the extent of the freezing region is critical since including the target tissue within the surgery scope is necessary for precise treatment and minimal damage to the surrounding normal tissue. This paper investigates a thermal wave based monitoring technique similar to the 3ω method for thermal property characterization in order to measure the extent of the freezing region. The method takes advantage of the contrast in thermal properties between the frozen and unfrozen regions and employs different locations on the circumference of the probe for the thermal wave generator and thermal wave sensor. A two-dimensional analytical model in cylindrical coordinates was developed for the thermal wave and was validated by finite element simulations. The analytical model was then employed to determine the influence of several parameters on determining the freezing extent including modulation frequency, the wave generator width, the relative locations of the thermal wave generator and sensor, and the diameter of the cryoprobe. The results obtained indicate the feasibility of the proposed technique since the amplitude and particularly the phase of the thermal wave signal are sensitive to the position of the interface between the frozen and unfrozen regions. For frozen and unfrozen layers with water, thermophysical properties of the measurement sensitive region extend to diameters in the cm range.
机译：冷冻胶是一种通过极端冻结消除不良组织的临床技术，表现出最小的入侵，快速恢复和低成本的优点。低温冷冻探针用于在靶组织周围形成冷冻区域。监测冷冻区域的程度至关重要，因为在手术范围内包括靶组织，对于精确的处理和对周围正常组织的最小损害是必要的。本文研究了类似于3Ω方法的热波的监测技术，以测量冰冻区域的范围。该方法利用冷冻和未冷区域之间的热性质的对比度，并在热波发生器和热波传感器的探针的圆周上采用不同的位置。为热波开发了圆柱形坐标的二维分析模型，并通过有限元模拟验证。然后采用分析模型来确定若干参数关于确定包括调制频率，波发生器宽度，热波发生器和传感器的相对位置的冻结程度的影响，以及冷冻探针的直径。获得的结果表明了所提出的技术的可行性，因为热波信号的幅度和特别是热波信号的相位对冷冻和未冷区之间的界面的位置敏感。对于用水的冷冻和未冷层，测量敏感区域的热物理性质延伸到CM范围内的直径。

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  • 来源
    《Journal of Applied Physics》 |2020年第18期|185101.1-185101.13|共13页
  • 作者

    Yi Zhang; Chengxi Wu; Theodorian Borca-Tasciuc;

  • 作者单位

    Department of Mechanical Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy New York 12180 USA;

    Department of Mechanical Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy New York 12180 USA;

    Department of Mechanical Aerospace and Nuclear Engineering Rensselaer Polytechnic Institute Troy New York 12180 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
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