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首页> 外文期刊>Journal of Autism and Developmental Disorders >Cortical Variability in the Sensory-Evoked Response in Autism
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Cortical Variability in the Sensory-Evoked Response in Autism

机译：自闭症的感觉诱发反应中的皮质变异性。

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摘要

Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.
机译：先前的发现表明，与典型对照参与者相比，自闭症谱系障碍（ASD）的患者在其诱发的fMRI反应中表现出更大的个体内变异（IIV）。我们用高功能自闭症成年人的新样本探索了这一发现的稳健性。在完成一项单向任务的同时，向参与者展示了扫描仪中的视觉，体感和听觉刺激。虽然ASD和对照组参与者的行为反应在统计学上没有区别，但新的ASD组相对于对照组的IIV更高。我们还表明，IIV在整个半球上是等效的，并且在整个实验过程中保持稳定。这表明更大的皮质IIV可能是自闭症感觉系统的可复制特征。

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