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Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica

机译:牙买加的母婴年龄与儿童自闭症共同相关

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摘要

Several studies have reported maternal and paternal age as risk factors for having a child with Autism Spectrum Disorder (ASD), yet the results remain inconsistent. We used data for 68 age- and sex-matched case–control pairs collected from Jamaica. Using Multivariate General Linear Models (MGLM) and controlling for parity, gestational age, and parental education, we found a significant (p 0.0001) joint effect of parental ages on having children with ASD indicating an adjusted mean paternal age difference between cases and controls of [5.9 years; 95% CI (2.6, 9.1)] and a difference for maternal age of [6.5 years; 95% CI (4.0, 8.9)]. To avoid multicollinearity in logistic regression, we recommend joint modeling of parental ages as a vector of outcome variables using MGLM.
机译:几项研究报告说,母亲和父亲的年龄是生育自闭症谱系障碍(ASD)的危险因素,但结果仍然不一致。我们使用了从牙买加收集的68对年龄和性别匹配的病例对照对的数据。使用多元通用线性模型(MGLM)并控制均等,胎龄和父母的教育,我们发现父母年龄对生有ASD的孩子具有显着的(p <0.0001)联合影响,表明病例与对照之间的平均父亲年龄差异得到了调整[5.9年; 95%CI(2.6,9.1)],孕产妇年龄差异为[6.5岁; 95%CI(4.0,8.9)]。为了避免逻辑回归中的多重共线性,我们建议使用MGLM将父母年龄的联合建模作为结果变量的向量。

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