首页> 外文期刊>Journal of Autism and Developmental Disorders >Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome
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Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome

机译:简要报告:特发性自闭症和易碎X综合征相关的感觉运动门控

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摘要

Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS−A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p < 0.002) and FXS−A (p < 0.003) groups had impaired PPI. The FXS+A (p < 0.01) and FXS−A (p < 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating.
机译:前脉冲抑制(PPI)可能有助于探索提议的特发性自闭症和FXS引起的自闭症之间的共享神经生物学。我们将PPI分为四组:典型的对照组(n = 18),FXS和自闭症(FXS + A; n = 15),无自闭症谱系障碍的FXS(FXS-A; n = 17)和特发性自闭症(IA; n = 15)。相对于对照组,FXS + A(p <0.002)和FXS-A(p <0.003)组的PPI受损。 FXS + A(p <0.01)和FXS-A(p <0.03)组的PPI比IA组低。 IA组发现惊吓潜伏期延长。在FXS + A和IA中看到的不同的PPI配置文件表明,这些组可能没有共同的感觉运动门控神经生物学异常。

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