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首页> 外文期刊>Journal of Autism and Developmental Disorders >The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample
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The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample

机译：自闭症特征与笨拙度之间协变的性质：在一般人群样本中的一项孪生研究

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摘要

While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63.
机译：虽然社交障碍，沟通困难和重复行为受限是自闭症谱系障碍的主要特征，但身体笨拙却是常见的共同特征。在来自意大利双生子注册中心的398对双生子（年龄在8-17岁之间）的样本中，我们研究了笨拙心理测量指数与儿童行为清单（CBCL）自闭症量表之间的协变量性质。双变量双胞胎分析显示，遗传病因重叠而不是直接因果关系，是笨拙和自闭症性状之间联系的合理解释，这是由父母评估的CBCL量表得出的。影响笨拙/运动问题和自闭症样特征的加性遗传影响显着重合，遗传相关性为0.63。

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  • 来源
    《Journal of Autism and Developmental Disorders》 |2011年第12期|p.1665-1674|共10页
  • 作者

    Sara Moruzzi; Anna Ogliari; Angelica Ronald; Francesca Happé; Marco Battaglia;

  • 作者单位

    The Academic Centre for the Study of Behavioural Plasticity, Vita-Salute San Raffaele University, 20 via S D’Ancona, 20127, Milan, Italy;

    The Academic Centre for the Study of Behavioural Plasticity, Vita-Salute San Raffaele University, 20 via S D’Ancona, 20127, Milan, Italy;

    Department of Psychological Sciences, Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK;

    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, London, UK;

    The Academic Centre for the Study of Behavioural Plasticity, Vita-Salute San Raffaele University, 20 via S D’Ancona, 20127, Milan, Italy;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Clumsiness; Autistic traits; CBCL; Comorbidity; Twin study;

    机译：笨拙;自闭症特征;CBCL;合并症;双胞胎研究;

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