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首页> 外文期刊>Journal of Autism and Developmental Disorders >Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder
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Brief Report: Glutamate Transporter Gene (SLC1A1) Single Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder

机译：简要报告：谷氨酸转运蛋白基因（SLC1A1）单核苷酸多态性（rs301430）与自闭症谱系障碍儿童的重复行为和焦虑

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摘要

Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive–compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
机译：谷氨酸转运蛋白基因（SLC1A1）中单核苷酸多态性（SNP）rs301430与自闭症谱系障碍（ASD）儿童的重复行为（强迫症，抽动）和焦虑严重程度相关。母亲和/或教师为67名自闭症谱系障碍儿童填写了经过验证的DSM-IV参考评分量表。尽管对于重复行为的分析并不重要，但高表达C等位基因纯合子的青年比T等位基因携带者的焦虑更为严重。 SLC1A1的等位基因变异可能是ASD儿童焦虑症状严重程度的生物标志物或调节剂，但最好将研究结果概念化为暂定待定，并与较大的独立样本一起复制。

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