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首页> 外文期刊>Journal of Autism and Developmental Disorders >Autonomic and Neuroendocrine Responses to a Psychosocial Stressor in Adults with Autistic Spectrum Disorder
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Autonomic and Neuroendocrine Responses to a Psychosocial Stressor in Adults with Autistic Spectrum Disorder

机译：患有自闭症谱系障碍的成年人对社会心理应激源的自主和神经内分泌反应

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摘要

Objective of the study was to replicate in adults our previous findings of decreased heart rate and normal endocrine responses to stress in autistic children and to elucidate the discrepancy between autonomic and endocrine stress responses by including epinephrine, norepinephrine, oxytocin and vasopressin measurements. Ten autistic spectrum disorder (ASD) adults were compared to 14 healthy controls in their response to a psychosocial stressor (public speaking). ASD patients showed decreased heart rate, but normal cortisol responses, consistent with our prior findings in children. No differences in norepinephrine, epinephrine, oxytocin or vasopressin responses to stress were found. However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors.
机译：该研究的目的是在成年人中复制我们以前在自闭症儿童中降低心率和正常内分泌对压力的反应的发现，并通过测量肾上腺素，去甲肾上腺素，催产素和加压素的含量来阐明自主神经和内分泌压力反应之间的差异。将十位自闭症谱系障碍（ASD）成人与14位健康对照者对社会心理压力源的反应进行了比较（公开演讲）。 ASD患者显示出心率降低，但皮质醇反应正常，这与我们先前在儿童中的发现一致。没有发现去甲肾上腺素，肾上腺素，催产素或加压素对应激反应的差异。然而，与先前在低功能自闭症儿童中的发现相反，ASD成人显示基础催产素水平升高，这可能与发育因素有关。

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  • 来源
    《Journal of Autism and Developmental Disorders》 |2006年第7期|891-899|共9页
  • 作者

    Lucres M. C. Jansen; Christine C. Gispen-de Wied; Victor M. Wiegant; Herman G. M. Westenberg; Bertine E. Lahuis; Herman van Engeland;

  • 作者单位

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

    Department of Child- and Adolescent Psychiatry Rudolf Magnus Institute of Neuroscience University Medical Center Utrecht The Netherlands;

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  • 正文语种 eng
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  • 关键词

    Autism; Adults; Stress; Physiology; Autonomic; Neuroendocrine;

    机译：自闭症;成人;压力;生理学;植物神经;神经内分泌;

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