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首页> 外文期刊>Journal of Autism and Developmental Disorders >Possible Association Between Congenital Cytomegalovirus Infection and Autistic Disorder
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Possible Association Between Congenital Cytomegalovirus Infection and Autistic Disorder

机译：先天性巨细胞病毒感染与自闭症之间的可能联系

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We encountered seven children with symptomatic congenital cytomegalovirus (CMV) infection from 1988 to 1995, of whom two (28.6%) developed typical autistic disorder. Case 1: A boy born at 38 weeks' gestation with a birth weight of 3164 g showed generalized petechiae, hepatosplenomegaly, and positive serum CMV-specific IgM antibodies. He was profoundly deaf, mentally retarded, and exhibited a lack of eye contact, stereotyped repetitive play, and hyperactivity. Case 2: A boy delivered at 39 weeks gestation with a birthweight of 2912 g showed non-progressive dilatation of the lateral ventricles observed postnatally. CMV-specific IgM antibodies were positive and CMV-DNA in the urine was confirmed by PCR. The boy was mentally retarded but not deaf. He showed no interest in people and delayed speech development. Subependymal cysts were detected by cranial ultrasound after birth in both patients. This is the first report describing subependymal cysts and the later development of AD. Cranial magnetic resonance imaging revealed an abnormal intensity area in the periventricular white matter suggestive of disturbed myelination; however, no migration disorders were found in our patients. These findings suggest that the timing of injury to the developing brain by CMV may be in the third trimester in some patients with autistic disorder.
机译：从1988年到1995年，我们遇到了7名有症状的先天性巨细胞病毒（CMV）感染儿童，其中有2名（28.6％）患有典型的自闭症。案例1：一个在38孕周出生的男孩，出生体重3164 g，表现出全身瘀斑，肝脾肿大和血清CMV特异性IgM抗体阳性。他严重失聪，智障，并且缺乏眼神交流，刻板的重复性游戏和活动过度。案例2：一名在39周妊娠时分娩的出生体重为2912 g的男孩表现出出生后观察到的侧脑室非进行性扩张。 CMV特异性IgM抗体呈阳性，尿液中的CMV-DNA通过PCR确认。这个男孩智障，但没有聋。他对人不感兴趣，并且语言发展迟缓。两名患者出生后均通过颅脑超声检查发现了室管膜下囊肿。这是第一个描述室管膜下囊肿和AD后来发展的报告。颅骨磁共振成像显示脑室周围白质强度区域异常，提示髓鞘形成紊乱。但是，在我们的患者中未发现任何迁徙障碍。这些发现表明，在某些自闭症患者中，CMV损伤大脑发育的时机可能在孕晚期。

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