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首页> 外文期刊>Journal of Bioinformatics and Computational Biology >TEMPERATURE-DEPENDENT STRUCTURAL VARIABILITY OF RNAs: SPLICED LEADER RNAs AND THEIR EVOLUTIONARY HISTORY
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TEMPERATURE-DEPENDENT STRUCTURAL VARIABILITY OF RNAs: SPLICED LEADER RNAs AND THEIR EVOLUTIONARY HISTORY

机译：RNA的温度依赖性结构变异性：拼接带帽RNA及其进化历史

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摘要

The structures attained by RNA molecules depend not only on their sequence but alsonon environmental parameters such as their temperature. So far, this effect has beennlargely neglected in bioinformatics studies. Here, we show that structural comparisonsncan be facilitated and more coherent structural models can be obtained when differencesnin environmental parameters are taken into account. We re-evaluate the secondarynstructures of the spliced leader (SL) RNAs from the seven eukaryotic phyla in whichnSL RNA trans-splicing has been described. Adjusting structure prediction to the naturalngrowth temperatures and considering energetically similar secondary structures, wenobserve striking similarities among Euglenida, Kinetoplastida, Dinophyceae, Cnidaria,nRotifera, Nematoda, Platyhelminthes, and Tunicata that cannot be explained easily byn1n2 M. Marz, N. Vanzo & P. F. Stadlernthe independent innovation of SL RNAs in each of these phyla. Supplementary Table isnavailable at http://www.worldscinet.com/jbcb/.
机译：RNA分子获得的结构不仅取决于其序列，还取决于非环境参数，例如其温度。到目前为止，在生物信息学研究中这种作用已被大大忽略。在这里，我们表明，当考虑到环境参数的差异时，可以促进结构比较，并且可以获得更连贯的结构模型。我们从其中已经描述了nSL RNA的七个真核门重新评估剪接的前导（SL）RNA的二级结构。调整结构预测以适应自然生长温度并考虑能量上相似的二级结构，我们发现尤格列尼达，动植物科，迪诺菌科，刺孢子虫，轮虫，线虫，鸭嘴兽和通尼塔克草之间的相似之处很难被n1n2 M. Marz，N.thethe Vanzo和PF解释。这些门中每个门的SL RNA的独立创新。补充表位于http://www.worldscinet.com/jbcb/。

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    MANJA MARZNATHALIE VANZOPETER F. STADLER;

  • 作者单位

    Bioinformatics Group, Department of Computer ScienceUniversity of Leipzig, H¨artelstraße 16-18D-04107 Leipzig, Germany;

    Centre de Biologie du D´eveloppementUMR 5547 C. N. R. S. Universit´e Paul SabatierF-31062 Toulouse Cedex, France;

    Bioinformatics Group, Department of Computer Scienceand Interdisciplinary Center for BioinformaticsUniversity of Leipzig, H¨artelstraße 16-18D-04107 Leipzig, GermanyMax Planck Institute for Mathematics in the SciencesInselstraße 22, D-04103 Leipzig, GermanyFraunhofer Institut f¨ur Zelltherapie und Immunologie – IZIPerlickstraße 1, D-04103 Leipzig, GermanyDepartment of Theoretical Chemistry, University of ViennaW¨ahringerstraße 17, A-1090 Wien, AustriaSanta Fe Institute, 1399 Hyde Park Rd.Santa Fe, NM 87501, USA;

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  • 正文语种 eng
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  • 关键词

    RNA folding; temperature dependence; SL RNA; trans-splicing; evolution;

    机译：RNA折叠;温度依赖性SL RNA;转拼演化;

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