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QUANTIFYING SLOW EVOLUTIONARY DYNAMICS IN RNA FITNESS LANDSCAPES

机译:量化RNA健身景观中的缓慢进化动力学

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We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an inverse power of the evolutionary time. In addition, our study of the trajectories shows that the out-of-equilibrium effects due to the evolutionary process are very weak. In particular, the distribution of genotypes is close to that arising during equilibrium stabilizing selection. As a consequence, the evolutionary dynamics leave almost no measurable out-of-equilibrium trace, only the transition genotypes (close to the border between different periods of stasis) have atypical mutational properties.
机译:我们重新检查向最佳RNA结构的方向选择下RNA二级结构的进化动力学。我们发现,标点均衡导致平均最优的演化时间的倒数次幂导致非常缓慢的最优解。此外,我们对轨迹的研究表明,由于进化过程而产生的失衡效应非常弱。特别地,基因型的分布接近于平衡稳定选择过程中产生的分布。结果,进化动力学几乎没有可测量的失衡轨迹,只有过渡基因型(靠近停滞期之间的边界)具有非典型的突变特性。

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