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首页> 外文期刊>Journal of Biological Physics >Charge Transport in Poly(dG)–Poly(dC) and Poly(dA)–Poly(dT) DNA Polymers
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Charge Transport in Poly(dG)–Poly(dC) and Poly(dA)–Poly(dT) DNA Polymers

机译:Poly(dG)–Poly(dC)和Poly(dA)–Poly(dT)DNA聚合物中的电荷传输

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摘要

We investigate the charge transport in synthetic DNA polymers built up from single type of base pairs. In the context of a polaronlike model, for which an electronic tight-binding system and bond vibrations of the double helix are coupled, we present estimates for the electron-vibration coupling strengths utilizing a quantum-chemical procedure. Subsequent studies concerning the mobility of polaron solutions, representing the state of a localized charge in unison with its associated helix deformation, show that the system for poly(dG)–poly(dC) and poly(dA)–poly(dT) DNA polymers, respectively possess quantitatively distinct transport properties. While the former supports unidirectionally moving electron breathers attributed to highly efficient long-range conductivity, the breather mobility in the latter case is comparatively restrained, inhibiting charge transport. Our results are in agreement with recent experimental results demonstrating that poly(dG)–poly(dC) DNA molecules acts as a semiconducting nanowire and exhibit better conductance than poly(dA)–poly(dT) ones.
机译:我们研究由单一类型的碱基对构建的合成DNA聚合物中的电荷传输。在极化子模型的背景下,电子紧密结合系统和双螺旋的键振动耦合,我们提出了利用量子化学方法估算电子振动耦合强度的方法。随后关于极化子溶液迁移率的研究表明了局部电荷的状态及其相关的螺旋变形,表明聚(dG)-聚(dC)和聚(dA)-聚(dT)DNA聚合物的体系分别具有定量不同的运输性质。前者支持归因于高效长距离电导率的单向移动电子呼吸器,而在后者情况下的呼吸器流动性受到相对限制,从而抑制了电荷传输。我们的结果与最近的实验结果相吻合,表明聚(dG)-聚(dC)DNA分子可作为半导体纳米线,并且比聚(dA)-聚(dT)具有更好的导电性。

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  • 来源
    《Journal of Biological Physics》 |2004年第3期|227-238|共12页
  • 作者单位

    Freie Universität Berlin Fachbereich Physik Institut für Theoretische Physik;

    Karolinska Institute Center for Structural Biochemistry NOVUM;

    Group of Nonlinear Physics Departamento de Física Aplicada I ETSI Informática Univesity of Sevilla;

    Group of Nonlinear Physics Departamento de Física Aplicada I ETSI Informática Univesity of Sevilla;

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