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Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging

机译:紧凑型超声引导的漫射光学层析成像系统,用于乳腺癌成像

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摘要

Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance,
机译:近红外漫射光学层析成像(DOT)已显示出巨大的潜力,可作为分化恶性和良性乳腺病变以及监测局部晚期乳腺癌患者治疗反应的辅助手段。 DOT技术商业化的道路取决于该技术在硬件和软件中的鲁棒性和用户友好性的提高。在这项研究中,我们介绍了我们最近开发的超声引导DOT系统,该系统通过定制设计的电子设备,自动数据预处理和新的两步重建算法的实施,在系统紧凑性,鲁棒性和用户友好性方面得到了改善。该系统的性能已经用几套固体和血液幻象进行了测试,结果显示了重构的吸收系数以及血氧饱和度的准确性。给出了正在接受新辅助化疗的乳腺癌患者的临床实例,以证明其系统性能,

著录项

  • 来源
    《Journal of biomedical optics》 |2019年第2期|021203.1-021203.9|共9页
  • 作者单位

    University of Connecticut, BME and ECE Departments, Connecticut, United States;

    Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States;

    University of Connecticut, BME and ECE Departments, Connecticut, United States;

    Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States;

    University of Connecticut, BME and ECE Departments, Connecticut, United States;

    New York City College of Technology, Brooklyn, New York, United States;

    University of Connecticut, BME and ECE Departments, Connecticut, United States;

    Washington University School of Medicine, Department of Medical Oncology, St. Louis, Missouri, United States;

    Washington University School of Medicine, Department of Radiology, St. Louis, Missouri, United States;

    Washington University in St. Louis, Department of Biomedical Engineering, St. Louis, Missouri, United States,Washington University School of Medicine, Department of Radiology, St. Louis, Missouri, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    diffuse optical tomography; ultrasound; near-infrared instrument; imaging reconstruction;

    机译:漫射光学层析成像超声波近红外仪器成像重建;

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