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Spatiotemporal laser speckle contrast analysis for blood flow imaging with maximized speckle contrast

机译：时空激光散斑对比分析，用于血流成像，散斑对比最大化

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摘要

Laser speckle contrast imaging is a technique used for imaging blood flow without scanning. Though several studies have attempted to combine spatial and temporal statistics of laser speckle images for reducing image noise as well as preserving acceptable spatiotemporal resolution, the statistical accuracy of these spatiotemporal methods has not been thoroughly compared. Through numerical simulation and animal experiments, this study investigates the changes in the mean speckle contrast values and the relative noise of the speckle contrast images computed by these methods with various numbers of frames and spatial windows. The simulation results show that the maximum relative error of the mean speckle contrast computed by the spatiotemporal laser speckle contrast analysis (STLASCA) method, in which the speckle contrast images are computed by analyzing the 3-D spatiotemporal speckle image cube, is approximately 5%, while it is higher than 13% for other methods. Changes in the mean speckle contrast values and the relative noise computed by these methods for animal experiment data are consistent with the simulation results. Our results demonstrate that STLASCA achieves more accurate speckle contrast, and suggest that STLASCA most effectively utilizes the number of pixels, thus achieving maximized speckle contrast, and thereby maximizing the variation of the laser speckle Contrast image.
机译：激光斑点对比成像是一种无需扫描即可成像血流的技术。尽管一些研究试图结合激光散斑图像的时空统计以减少图像噪声并保持可接受的时空分辨率，但是这些时空方法的统计准确性尚未得到全面比较。通过数值模拟和动物实验，本研究调查了在各种数量的帧和空间窗口下，这些方法计算出的平均斑点对比度值的变化和斑点对比度图像的相对噪声。仿真结果表明，通过时空激光散斑对比度分析（STLASCA）方法计算的平均散斑对比度的最大相对误差约为5％，在该方法中，通过分析3-D时空散斑图像立方体来计算散斑对比度图像。 ，而其他方法则高于13％。用这些方法为动物实验数据计算的平均斑点对比度值的变化和相对噪声与模拟结果一致。我们的结果表明，STLASCA可实现更准确的斑点对比度，并表明STLASCA最有效地利用了像素数量，从而实现了最大的斑点对比度，从而最大化了激光斑点对比度图像的变化。

著录项

  • 来源
    《Journal of biomedical optics》 |2010年第1期|p.016003.1-016003.5|共5页
  • 作者

    Jianjun Qiu; Pengcheng Li; Weihua Luo; Jia Wang; Hongyan Zhang; Qingming Luo;

  • 作者单位

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

    Huazhong University of Science and Technology Wuhan National Laboratory for Optoelectronics Britton Chance Center for Biomedical Photonics Wuhan 430074 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    laser speckle contrast imaging; speckle contrast; spatiotemporal resolution; statistical accuracy;

    机译：激光散斑对比成像斑点对比时空分辨率统计准确性;

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