Early versus late administration of pegfilgrastim after high-dose chemotherapy and autologous hematopoietic stem cell transplantation

C. Kahl; H. G. Sayer; A. Hinke; M. Freund; J. Casper

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Early versus late administration of pegfilgrastim after high-dose chemotherapy and autologous hematopoietic stem cell transplantation

机译：大剂量化疗和自体造血干细胞移植后早期和晚期给予培非非司亭

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摘要

Single-dose pegylated filgrastim (pegfilgrastim) after autologous hematopoietic stem cell transplantation (AHSCT) showed similar efficacy compared to daily lenograstim. To address the question of the optimal application time, we randomly assigned patients (pts) to pegfilgrastim on day + 1 (Peg1) or day + 4 (Peg4) after AHSCT.

机译：自体造血干细胞移植（AHSCT）后的单剂量聚乙二醇化非格司亭（pegfilgrastim）与每天的lenograstim相比显示出相似的功效。为了解决最佳应用时间的问题，我们在AHSCT后第1天（Peg1）或第4天（Peg4）随机分配患者（pts）。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2012年第3期|p.513-517|共5页
作者
C. Kahl; H. G. Sayer; A. Hinke; M. Freund; J. Casper;
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作者单位

Department of Hematology and Oncology, Klinikum Magdeburg, Birkenallee 34, 39130, Magdeburg, Germany;

WiSP Research Institute, Langenfeld, Germany;

3rd Medical Department, University of Rostock, Rostock, Germany;

Department of Hematology and Oncology, Klinikum Oldenburg, Oldenburg, Germany;

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正文语种 eng
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Colony stimulating factor; Hematopoietic growth factor; Pegfilgrastim; Autologous hematopoietic stem cell transplantation; AHSCT; Hematological malignancies;

机译：菌落刺激因子;造血生长因子;培非司亭;自体造血干细胞移植;AHSCT;血液系统恶性肿瘤;

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1. Early versus late administration of pegfilgrastim after high-dose chemotherapy and autologous hematopoietic stem cell transplantation. [J] . C Kahl, H G Sayer, A Hinke, Journal of Cancer Research and Clinical Oncology . 2012,第3期

机译：大剂量化疗和自体造血干细胞移植后早期和晚期施用培非非司亭。
2. Cost effectiveness of pegfilgrastim versus filgrastim after high-dose chemotherapy and autologous stem cell transplantation in patients with lymphoma and myeloma: An economic evaluation of the PALM trial [J] . PerrierL., LefrancA., PérolD., Applied health economics and health policy . 2013,第2期

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3. A single dose of Pegfilgrastim versus daily Filgrastim to evaluate the mobilization and the engraftment of autologous peripheral hematopoietic progenitors in malignant lymphoma patients candidate for high-dose chemotherapy. [J] . Simona B, Cristina R, Luca N, Transfusion and apheresis science: official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis . 2010,第3期

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5. Posttraumatic stress disorder and sub-syndromal trauma symptoms in cancer patients treated with autologous hematopoietic stem cell transplant and standard dose chemotherapy. [D] . Gourvitz, Ross L. 2008

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7. Pegfilgrastim versus filgrastim to accelerate hematopoietic recovery after high-dose melphalan and autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma [O] . Olin R.L., Luger S.M., Porter D.L., 2005

机译：大剂量美法仑和自体造血干细胞移植（ASCT）治疗多发性骨髓瘤后，培格非司亭和非格司亭可加速造血恢复

Early versus late administration of pegfilgrastim after high-dose chemotherapy and autologous hematopoietic stem cell transplantation

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