Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo

Yong-Wei Wang; Shuang-Jia Wang; Yi-Nan Zhou; Shang-Ha Pan; Bei Sun

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Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo

机译：Escin通过下调体内和体外胰腺癌中核因子-κB和核因子-κB调控的基因产物来增强吉西他滨的疗效

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Pancreatic cancer is an aggressive malignancy, which generally develops resistance to chemotherapy. Agents that are safe and can sensitize cancer to chemotherapy are urgently needed. Escin, a natural mixture of triterpene saponins isolated from Aesculus wilsonii Rehd, has been demonstrated to possess anti-cancer activity both in vitro and in vivo. The anti-cancer activity of escin could be, in part, due to the inactivation of nuclear factor-κB (NF-κB). In contrast, chemotherapy including gemcitabine could activate NF-κB and lead to chemoresistance. Here, for the first time, we investigated whether escin, via the inactivation of NF-κB, would potentiate the antitumor activity of gemcitabine in pancreatic cancer.

机译：胰腺癌是一种侵袭性恶性肿瘤，通常会产生对化学疗法的抵抗力。迫切需要安全并且可以使癌症对化疗敏感的药物。 Escin是从欧洲七叶树（Aesculus wilsonii Rehd）分离出的三萜皂苷的天然混合物，已被证明在体外和体内均具有抗癌活性。七叶红素的抗癌活性可能部分归因于核因子-κB（NF-κB）的失活。相反，包括吉西他滨的化学疗法可以激活NF-κB并导致化学耐药性。在这里，我们首次研究了七叶皂苷是否通过灭活NF-κB来增强吉西他滨在胰腺癌中的抗肿瘤活性。

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来源
《Journal of Cancer Research and Clinical Oncology》 |2012年第5期|p.785-797|共13页
作者
Yong-Wei Wang; Shuang-Jia Wang; Yi-Nan Zhou; Shang-Ha Pan; Bei Sun;
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作者单位

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of China;

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of China;

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of China;

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of China;

Department of Pancreatic and Biliary Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 23 Youzheng Str, Nangang, Harbin, People’s Republic of China;

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正文语种 eng
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关键词
Pancreatic cancer; Escin; Gemcitabine; Nuclear factor-κB;

机译：胰腺癌;埃斯汀;吉西他滨;核因子-κB;

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专利

1. Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo. [J] . Yong-Wei Wang, Shuang-Jia Wang, Yi-Nan Zhou, Journal of Cancer Research and Clinical Oncology . 2012,第5期

机译：Escin通过下调体内和体外胰腺癌中核因子-κB和核因子-κB调控的基因产物来增强吉西他滨的疗效。
2. Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity [J] . DuQ.-H., XuY.-B., ZhangM.-Y., World journal of gastroenterology : . 2013,第33期

机译：异丙酚通过抑制核因子-κB活性诱导胰腺癌细胞凋亡并提高吉西他滨敏感性
3. Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κB activity [J] . DuQ.-H., XuY.-B., ZhangM.-Y., World journal of gastroenterology : . 2013,第33期

机译：丙比罗诱导细胞凋亡，通过抑制核因子-κB活性，在体外提高胰腺癌细胞中的吉西他滨敏感性
4. Anti-inflammatory Activity of Salvianic acid A through the Inhibition of Nuclear Factor-κB Activation in Peritoneal Macrophage [C] . Jun Yuan, Ji-Hong Yao, Qin Zhou, The 3rd International Conference on Bioinformatics and Biomedical Engineering(iCBBE 2009)(第三届生物信息与生物医学工程国际会议）论文集 . 2009

机译：丹参酸A通过抑制腹膜巨噬细胞核因子-κB活化而具有抗炎活性
5. Nuclear Factor-κB Promotes Urothelial Tumorigenesis and Cancer Progression via Cooperation with Androgen Receptor Signaling [D] . Inoue Satoshi, 井上聡 2019

机译：核因子-κB通过与雄激素受体信号传导协同促进尿路上皮肿瘤发生和癌症进展。
6. Bhardwaj A Sethi G Vadhan-Raj S et al. Resveratrol inhibits proliferation induces apoptosis and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. 2007;109(6):2293-2302. [O] . -1

机译：Bhardwaj ASethi GVadhan-Raj S等。白藜芦醇通过下调人多发性骨髓瘤细胞中的STAT3和核因子-κB调节的抗凋亡和细胞存活基因产物抑制增殖诱导细胞凋亡并克服化学抗性。血液。 2007； 109（6）：2293-2302。
7. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB–regulated gene products in IFN-α–sensitive and IFN-α–resistant human bladder cancer cells [O] . Ashish M. Kamat, Gautam Sethi, Bharat B. Aggarwal 2007

机译：姜黄素增强了化学治疗剂和细胞因子的凋亡作用通过IFN-α敏感和IFN-α-抗性的人膀胱癌细胞的核因子-κB和核因子-κB-调节基因产物的调节

Escin augments the efficacy of gemcitabine through down-regulation of nuclear factor-κB and nuclear factor-κB-regulated gene products in pancreatic cancer both in vitro and in vivo

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