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首页> 外文期刊>Journal of Chemical Crystallography >Synthesis and Structure of 2-Cyclohexylamino-3-methyl-1,1-diphenyl-butan-1-ol (d-N-Cyclohexyl-diphenylvalinol), an Amino Alcohol Ligand Useful in Asymmetric Catalysis
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Synthesis and Structure of 2-Cyclohexylamino-3-methyl-1,1-diphenyl-butan-1-ol (d-N-Cyclohexyl-diphenylvalinol), an Amino Alcohol Ligand Useful in Asymmetric Catalysis

机译:用于不对称催化的氨基醇配体2-环己基氨基-3-甲基-1,1-二苯基-丁-1-醇(d-N-环己基-二苯基戊醇)的合成与结构

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摘要

Amino alcohols are important ligands for the asymmetric catalytic hydroamination of aminoallenes to form chiral pyrrolidines. The amino alcohol d-N-cyclohexyl-diphenylvalinol was synthesized and crystallized by slow evaporation from a 7:1 ether:ethanol mixture. The molecule crystallizes in the monoclinic space group P2 1 with unit cell parameters a = 8.0724(8) Å, b = 14.4327(14) Å, c = 8.6752(9) Å and β = 107.098(2)° and contains one molecule in the asymmetric unit with all constituent atoms being on general positions. Close inspection of the solid-state structure revealed a strong intramolecular hydrogen bond between the hydrogen atom of the hydroxyl group and the amine nitrogen.
机译:氨基醇是氨基丙烯不对称催化加氢胺化形成手性吡咯烷的重要配体。合成了氨基醇d-N-环己基-二苯基戊醇,并通过缓慢蒸发从7:1的醚:乙醇混合物中结晶。该分子在单斜晶空间群P2 1 中结晶,其晶胞参数为a = 8.0724(8),b = 14.4327(14),c = 8.6752(9),β= 107.098(2)°,在不对称单元中包含一个分子,所有组成原子均位于一般位置。仔细检查固态结构,发现羟基的氢原子与胺氮之间存在强大的分子内氢键。

著录项

  • 来源
    《Journal of Chemical Crystallography》 |2012年第9期|p.911-915|共5页
  • 作者单位

    Department of Chemistry, The W.M. Keck Foundation Center for Molecular Structure, California State Polytechnic University, 3801 W. Temple Ave., Pomona, CA, 91768, USA;

    Department of Chemistry, Harvey Mudd College, 301 Platt Blvd., Claremont, CA, 91711, USA;

    Department of Chemistry, Harvey Mudd College, 301 Platt Blvd., Claremont, CA, 91711, USA;

    Department of Chemistry and Biochemistry, The W.M. Keck Foundation Center for Molecular Structure, California State University, 800 N. State College Blvd., Fullerton, CA, 92831, USA;

    Department of Chemistry, The W.M. Keck Foundation Center for Molecular Structure, California State Polytechnic University, 3801 W. Temple Ave., Pomona, CA, 91768, USA;

    Department of Chemistry, Harvey Mudd College, 301 Platt Blvd., Claremont, CA, 91711, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Hydroamination; Asymmetric catalysis; Chirality;

    机译:加氢胺;不对称催化;官能度;

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