Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes

Paul Eggleton; Lorna W. Harries; Giada Alberigo; Paul Wordsworth; Nick Viner; Richard Haigh; Suzanne Donnelly; Hugh W. Jones; Ian C. Chikanza; Thomas W. E. O’Conner

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Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes

机译：与健康淋巴细胞相比，类风湿关节炎和系统性红斑狼疮患者淋巴细胞凋亡基因表达的变化

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Introduction Systemic lupus erythematosus (SLE) and rheumatoid arthritis have complex genetic traits, but in both autoimmune diseases, dysfunctional apoptosis appears to play a part in disease pathology. This study examined the levels of in vitro apoptosis in lymphocytes from healthy, rheumatoid arthritis (RA) and SLE individuals and related observed differences to their lymphocyte apoptosis gene profiles.

机译：简介系统性红斑狼疮（SLE）和类风湿性关节炎具有复杂的遗传特征，但是在两种自身免疫性疾病中，功能失调的细胞凋亡似乎都在疾病病理中起作用。这项研究检查了健康，类风湿性关节炎（RA）和SLE个体淋巴细胞的体外凋亡水平，并观察到了与其淋巴细胞凋亡基因谱相关的差异。

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来源
《Journal of Clinical Immunology》 |2010年第5期|p.649-658|共10页
作者
Paul Eggleton; Lorna W. Harries; Giada Alberigo; Paul Wordsworth; Nick Viner; Richard Haigh; Suzanne Donnelly; Hugh W. Jones; Ian C. Chikanza; Thomas W. E. O’Conner;
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正文语种 eng
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DEDD2 up; regulation; PYCARD down; regulation; pyknosis; real; time PCR; lymphocytes; lupus; rheumatoid arthritis;

机译：DEDD2 up;调节PYCARD下降;调节;缩;实时PCR;淋巴细胞;狼疮;类风湿关节炎;

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1. Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. [J] . Eggleton P, Harries LW, Alberigo G, Journal of Clinical Immunology . 2010,第5期

机译：与健康淋巴细胞相比，类风湿性关节炎和系统性红斑狼疮患者淋巴细胞凋亡基因表达的变化。
2. Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus [J] . Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, Clinical & developmental immunology. . 2018,第1期

机译：健康个体氯化钠摄入和Treg / Th17淋巴细胞的分析及风湿性关节炎或全身性狼疮红斑狼疮患者
3. Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus [J] . Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, Journal of immunology research. . 2018,第6期

机译：健康个体和类风湿关节炎或系统性红斑狼疮患者的氯化钠摄入量和Treg / Th17淋巴细胞分析
4. Rheumatoid Arthritis T-lymphocytes "Immature" Phenotype and Attempt of its Correction in Go-culture with Human Thymic Epithelial Cells [C] . M.V. Goloviznin, N.S. Lakhonina, N.I. Sharova International Conference on Biomedical Engineering . 2008

机译：类风湿性关节炎T淋巴细胞“未成熟”表型及其对人胸腺上皮细胞的去培养中的矫正尝试
5. An increase in the frequency of hprt mutant T lymphocytes in the peripheral blood, synovial fluid, and synovial tissue of rheumatoid arthritis patients. [D] . Cannons, Jennifer. 1997

机译：类风湿性关节炎患者外周血，滑液和滑膜组织中hprt突变T淋巴细胞的频率增加。
6. Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus [O] . Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, 2018

机译：健康个体和类风湿关节炎或系统性红斑狼疮患者的氯化钠摄入量和Treg / Th17淋巴细胞分析
7. Analysis of Sodium Chloride Intake and Treg/Th17 Lymphocytes in Healthy Individuals and Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus [O] . Marlen Vitales-Noyola, Esther Layseca-Espinosa, Lourdes Baranda, 2018

机译：健康个体氯化钠摄入和Treg / Th17淋巴细胞的分析及风湿性关节炎或全身性狼疮红斑狼疮患者

Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes

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