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首页> 外文期刊>Journal of Cognitive Neuroscience >Muscle and Timing-specific Functional Connectivity between the Dorsolateral Prefrontal Cortex and the Primary Motor Cortex
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Muscle and Timing-specific Functional Connectivity between the Dorsolateral Prefrontal Cortex and the Primary Motor Cortex

机译：背外侧前额叶皮层和初级运动皮层之间的肌肉和时序特定的功能连接

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The pFC has a crucial role in cognitive control, executive function, and sensory processing. Functional imaging, neurophysiological, and animal studies provide evidence for a functional connectivity between the dorsolateral pFC (DLPFC) and the primary motor cortex (M1) during free choice but not instructed choice selection tasks. In this study, twin coil, neuronavigated TMS was used to examine the precise timing of the functional interaction between human left DLPFC and ipsilateral M1 during the execution of a free/specified choice selection task involving the digits of the right hand. In a thumb muscle that was not involved in the task, a conditioning pulse to the left DLPFC enhanced the excitability of the ipsilateral M1 during free selection more than specified selection 100 msec after presentation of the cue; the opposite effect was seen at 75 msec. However, the difference between free and externally specified conditions disappeared when a task-specific muscle was investigated. In this case, the influence from DLPFC was dominated by task involvement rather than mode of selection, suggesting that other processes related to movement execution were also operating. Finally, we show that the effects were spatially specific because they were absent when an adjacent area of DLPFC was stimulated. These results reveal temporally and spatially selective interactions between BA 46 and M1 that are both task and muscle specific.
机译：pFC在认知控制，执行功能和感觉处理中具有至关重要的作用。功能性影像学，神经生理学和动物研究为自由选择过程中背侧pFC（DLPFC）和初级运动皮层（M1）之间的功能连接提供了证据，但没有指导性的选择任务。在这项研究中，使用双线圈，神经导航TMS来检查在执行涉及右手手指的自由/指定选择选择任务期间，人类左DLPFC和同侧M1之间的功能相互作用的精确时机。在不参与这项任务的拇指肌肉中，向左DLPFC施加条件脉冲可在提示提示后100毫秒内自由选择期间增强同侧M1的兴奋性，使其超过指定的选择。在75毫秒时看到了相反的效果。但是，当研究特定任务的肌肉时，自由和外部指定条件之间的差异消失了。在这种情况下，来自DLPFC的影响主要由任务参与而不是选择模式决定，这表明与动作执行有关的其他流程也在运行。最后，我们证明了这种影响在空间上是特定的，因为当刺激DLPFC的相邻区域时它们不存在。这些结果揭示了BA 46和M1在时间和空间上的选择性交互作用，这些交互作用既是任务又是肌肉。

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