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首页> 外文期刊>Journal of Computational Neuroscience >A unified model for two modes of bursting in GnRH neurons
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A unified model for two modes of bursting in GnRH neurons

机译：GnRH神经元的两种爆发模式的统一模型

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Gonadotropin-releasing hormone (GnRH) neurons exhibit at least two intrinsic modes of action potential burst firing, referred to as parabolic and irregular bursting. Parabolic bursting is characterized by a slow wave in membrane potential that can underlie periodic clusters of action potentials with increased interspike interval at the beginning and at the end of each cluster. Irregular bursting is characterized by clusters of action potentials that are separated by varying durations of interburst intervals and a relatively stable baseline potential. Based on recent studies of isolated ionic currents, a stochastic Hodgkin-Huxley (HH)-like model for the GnRH neuron is developed to reproduce each mode of burst firing with an appropriate set of conductances. Model outcomes for bursting are in agreement with the experimental recordings in terms of interburst interval, interspike interval, active phase duration, and other quantitative properties specific to each mode of bursting. The model also shows similar outcomes in membrane potential to those seen experimentally when tetrodotoxin (TTX) is used to block action potentials during bursting, and when estradiol transitions cells exhibiting slow oscillations to irregular bursting mode in vitro. Based on the parameter values used to reproduce each mode of bursting, the model suggests that GnRH neurons can switch between the two through changes in the maximum conductance of certain ionic currents, notably the slow inward Ca2+ current I (s,) and the Ca2+ -activated K+ current I (KCa). Bifurcation analysis of the model shows that both modes of bursting are similar from a dynamical systems perspective despite differences in burst characteristics.
机译：促性腺激素释放激素（GnRH）神经元表现出至少两种内在的动作电位爆发模式，称为抛物线和不规则爆发。抛物线爆发的特征是膜电位的缓慢波动，它可以作为动作电位的周期性簇的基础，在每个簇的开始和结束时，穗间间隔增加。不规则爆发的特征是动作电位簇，这些动作电位通过不同的爆发间隔时间和相对稳定的基线电位而分开。基于隔离离子电流的最新研究，开发了GnRH神经元的随机Hodgkin-Huxley（HH）样模型，以用适当的电导集重现每种爆发模式。爆裂的模型结果与爆破间隔，突刺间隔，活动相持续时间以及每种爆破模式特有的其他定量特性方面的实验记录相符。该模型还显示出膜电位的结局，与使用河豚毒素（TTX）阻止爆发过程中的动作电位，以及当雌二醇将细胞显示缓慢振荡的细胞转变为体外不规则爆发模式时的实验结果相似。根据用于重现每种爆发模式的参数值，该模型表明，GnRH神经元可以通过某些离子电流的最大电导率的变化在两者之间切换，特别是缓慢的内向Ca2 +电流I（s，）和Ca2 +-激活的K +电流I（KCa）。对模型的分叉分析表明，尽管爆发特性有所不同，但从动力系统的角度来看，两种爆发模式都是相似的。

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