A simple integrative electrophysiological model of bursting GnRH neurons

David Csercsik; Imre Farkas; Erik Hrabovszky; Zsolt Liposits

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A simple integrative electrophysiological model of bursting GnRH neurons

机译：爆发性GnRH神经元的简单综合电生理模型

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In this paper a modular model of the GnRH neuron is presented. For the aim of simplicity, the currents corresponding to fast time scales and action potential generation are described by an impulsive system, while the slower currents and calcium dynamics are described by usual ordinary differential equations (ODEs). The model is able to reproduce the depolarizing afterpotentials, afterhyperpolarization, periodic bursting behavior and the corresponding calcium transients observed in the case of GnRH neurons.

机译：在本文中，提出了GnRH神经元的模块化模型。为了简单起见，对应于快速时标和动作电位生成的电流由脉冲系统描述，而较慢的电流和钙动力学则由通常的常微分方程（ODE）描述。该模型能够重现GnRH神经元的去极化后电位，超极化后，周期性爆发行为以及相应的钙瞬变。

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《Journal of Computational Neuroscience》 |2012年第1期|p.119-136|共18页
作者
David Csercsik; Imre Farkas; Erik Hrabovszky; Zsolt Liposits;
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作者单位

Process Control Research Group, Computer and Automation Research Institute, Hungarian Academy of Sciences, P.O. Box 63,1518 Budapest, Hungary;

Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences,P.O. Box 67,1450 Budapest, Hungary;

Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences,P.O. Box 67,1450 Budapest, Hungary;

Department of Endocrine Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences,P.O. Box 67,1450 Budapest, Hungary,Faculty of Information Technology, Pazmany Peter Catholic University, P.O. Box 178,1364 Budapest, Hungary;

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正文语种 eng
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关键词
gonadotropin-releasing hormone; dynamic modelling; bursting;

机译：促性腺激素释放激素动态建模爆裂;

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1. A unified model for two modes of bursting in GnRH neurons [J] . Moran Spencer, Moenter Suzanne M., Khadra Anmar Journal of Computational Neuroscience . 2016,第3期

机译：GnRH神经元的两种爆发模式的统一模型
2. An integrated model of electrical spiking, bursting, and calcium oscillations in GnRH neurons. [J] . Fletcher PA, Li YX Biophysical Journal . 2009,第11期

机译：GnRH神经元中的电峰值，爆发和钙振荡的集成模型。
3. Geometrical analysis of bursting pacemaker neurons generated by computational models: comparison to in vitro pre-Botzinger complex bursting neurons. [J] . Cordovez JM, Wilson CG, Solomon IC Advances in Experimental Medicine and Biology . 2010,第Null期

机译：计算模型产生的爆破起搏器神经元的几何分析：与体外前僵菌复合物爆破神经元的比较。
4. Calcium Coupled Bursting in an Integrative Model of GnRH Neuronal Electrophysiology [C] . D. Csercsik, I. Farkas European Conference of the International Federation for Medical and Biological Engineering . 2013

机译：GnRH神经元电生理学一体化模型中的钙耦合突发
5. Analysis of complex bursting patterns in multiple timescale respiratory neuron models. [D] . Wang, Yangyang. 2016

机译：在多个时间尺度呼吸神经元模型中分析复杂的爆发模式。
6. An Integrated Model of Electrical Spiking Bursting and Calcium Oscillations in GnRH Neurons [O] . Patrick A. Fletcher, Yue-Xian Li 2009

机译：GnRH神经元的电脉冲爆发和钙振荡的集成模型
7. A simple integrative electrophysiological model of bursting GnRH neurons [O] . Csercsik Dávid, Farkas Imre, Hrabovszky Erik, 2012

机译：爆发性GnRH神经元的简单整合电生理模型

A simple integrative electrophysiological model of bursting GnRH neurons

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