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首页> 外文期刊>Journal of Computational Neuroscience >Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment
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Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment

机译：多轴模型中的动作电位启动，轴突初始段中的Na通道协同门控

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Somatic action potentials (AP) of cortical pyramidal neurons have characteristically high onset-rapidness. The onset of the AP waveform is an indirect measure for the ability of a neuron to respond to temporally fast-changing stimuli. Theoretical studies on the pyramidal neuron response usually involves a canonical Hodgkin-Huxley (HH) type ion channel gating model, which assumes statistically independent gating of each individual channel. However, cooperative activity of ion channels are observed for various cell types, meaning that the activity (e.g. opening) of one channel triggers the activity (e.g. opening) of a certain fraction of its neighbors and hence, these groups of channels behave as a unit. In this study, we describe a multi-compartmental conductance-based model with cooperatively gating voltage-gated Na channels in the axon initial segment. Our model successfully reproduced the somatic sharp AP onsets of cortical pyramidal neurons. The onset latencies from the initiation site to the soma and the conduction velocities were also in agreement with the previous experimental studies.
机译：皮质锥体神经元的体细胞动作电位（AP）具有快速发作的特征。 AP波形的开始是神经元对时间快速变化的刺激做出反应的能力的间接度量。锥体神经元反应的理论研究通常涉及规范的霍奇金-赫克斯利（HH）型离子通道门控模型，该模型假设每个单独通道的统计独立门控。但是，对于各种细胞类型，都可以观察到离子通道的协同活性，这意味着一个通道的活性（例如，打开）会触发一定比例的邻居的活性（例如，打开），因此，这些通道组的行为是一个单元。在这项研究中，我们描述了一个基于多室电导的模型，该模型在轴突初始段中协同门控电压门控Na通道。我们的模型成功地再现了皮层锥体神经元的体细胞尖锐AP发作。从起始部位到躯体的发作潜伏期和传导速度也与先前的实验研究一致。

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