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首页> 外文期刊>Journal of Computational Neuroscience >Gap junction permeability modulated by dopamine exerts effects on spatial and temporal correlation of retinal ganglion cells' firing activities
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Gap junction permeability modulated by dopamine exerts effects on spatial and temporal correlation of retinal ganglion cells' firing activities

机译：多巴胺调节的间隙连接通透性影响视网膜神经节细胞放电活动的时空相关性

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摘要

Synchronized activities among retinal ganglion cells (RGCs) via gap junctions can be increased by exogenous dopamine (DA). During DA application, single neurons' firing activities become more synchronized with its adjacent neighbors. One intriguing question is how the enhanced spatial synchronization alters the temporal firing structure of single neurons. In the present study, firing activities of bullfrog's dimming detectors in response to binary pseudo-random checker-board flickering were recorded via a multi-channel recording system. DA was applied in the retina to modulate synchronized activities between RGCs, and the effect of DA on firing activities of single neurons was examined. It was found that, during application of DA, synchronized activities between single neuron and its neighboring neurons was enhanced. At the meantime, the temporal structures of single neuron spike train changed significantly, and the temporal correlation in single neuron's response decreased. The pharmacological study results indicated that the activation of D1 receptor might have effects on gap junction permeability between RGCs. Our results suggested that the dopaminergic pathway participated in the modulation of spatial and temporal correlation of RGCs' firing activities, and may exert critical effects on visual information processing in the retina.
机译：视网膜神经节细胞（RGC）之间通过间隙连接的同步活动可以通过外源性多巴胺（DA）增强。在DA应用过程中，单个神经元的放电活动与其相邻邻居的同步性更高。一个有趣的问题是增强的空间同步如何改变单个神经元的时间触发结构。在本研究中，通过多通道记录系统记录了牛蛙调光检测器对二进制伪随机棋盘闪烁的响应。将DA应用于视网膜以调节RGC之间的同步活动，并检查DA对单个神经元放电活动的影响。发现在DA的应用期间，单个神经元与其相邻神经元之间的同步活动被增强。同时，单个神经元尖峰序列的时间结构发生了显着变化，单个神经元反应的时间相关性降低。药理研究结果表明D1受体的激活可能对RGC之间的间隙连接渗透性有影响。我们的研究结果表明，多巴胺能途径参与了RGC放电活动时空相关性的调节，并且可能对视网膜的视觉信息处理产生关键影响。

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  • 来源
    《Journal of Computational Neuroscience》 |2014年第1期|67-79|共13页
  • 作者

    Jing-Yi Bu; Hao Li; Hai-Qing Gong; Pei-Ji Liang; Pu-Ming Zhang;

  • 作者单位

    School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China;

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  • 正文语种 eng
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  • 关键词

    Temporal correlation; Spatial correlation; Multi-channel recording; Retinal ganglion cell; Dopamine;

    机译：时间相关;空间相关性;多通道录音;视网膜神经节细胞;多巴胺;

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