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首页> 外文期刊>Journal of Computational Neuroscience >A molecular level prototype for mechanoelectrical transducer in mammalian hair cells
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A molecular level prototype for mechanoelectrical transducer in mammalian hair cells

机译：哺乳动物毛细胞中机电换能器的分子水平原型

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The mechanoelectrical transducer (MET) is a crucial component of mammalian auditory system. The gating mechanism of the MET channel remains a puzzling issue, though there are many speculations, due to the lack of essential molecular building blocks. To understand the working principle of mammalian MET, we propose a molecular level prototype which constitutes a charged blocker, a realistic ion channel and its surrounding membrane. To validate the proposed prototype, we make use of a wellestablished ion channel theory, the Poisson-Nernst-Planck equations, for three-dimensional (3D) numerical simulations. A wide variety of model parameters, including bulk ion concentration, applied external voltage, blocker charge and blocker displacement, are explored to understand the basic function of the proposed MET prototype. We show that our prototype prediction of channel open probability in response to blocker relative displacement is in remarkable accordance with experimental observation of rat cochlea outer hair cells. Our results appear to suggest that tip links which connect hair bundles gate MET channels.
机译：机电转换器（MET）是哺乳动物听觉系统的重要组成部分。尽管有许多猜测，但由于缺乏必要的分子构件，MET通道的门控机制仍然是一个令人费解的问题。为了了解哺乳动物MET的工作原理，我们提出了一种分子水平的原型，该原型构成带电的阻滞剂，真实的离子通道及其周围的膜。为了验证所提出的原型，我们利用完善的离子通道理论，即Poisson-Nernst-Planck方程，进行了三维（3D）数值模拟。探索了各种模型参数，包括体离子浓度，施加的外部电压，阻滞剂​​电荷和阻滞剂位移，以了解拟议的MET原型的基本功能。我们表明，响应于阻滞剂的相对位移，我们对通道开放概率的原型预测与大鼠耳蜗外毛细胞的实验观察结果明显不同。我们的结果似乎表明，连接发束的尖端链接可控制MET通道。

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