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首页> 外文期刊>Journal of Computational Neuroscience >Probabilistic modeling of selective stimulation of the human sciatic nerve with a flat interface nerve electrode
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Probabilistic modeling of selective stimulation of the human sciatic nerve with a flat interface nerve electrode

机译：扁平界面神经电极选择性刺激人坐骨神经的概率模型

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摘要

Ankle control is critical to both standing balance and efficient walking. The hypothesis presented in this paper is that a Flat Interface Nerve Electrode (FINE) placed around the sciatic nerve with a fixed number of contacts at predetermined locations and without a priori knowledge of the nerve's underlying neuroanatomy can selectively control each ankle motion. Models of the human sciatic nerve surrounded by a FINE of varying size were created and used to calculate the probability of selective activation of axons within any arbitrarily designated, contiguous group of fascicles. Simulations support the hypothesis and suggest that currently available implantable technology cannot selectively recruit each target plantar flexor individually but can restore plantar flexion or dorsiflexion from a site on the sciatic nerve without spillover to antagonists. Successful activation of individual ankle muscles in 90% of the population can be achieved by utilizing bipolar stimulation and/ or by using a cuff with at least 20 contacts.
机译：脚踝控制对于保持站立平衡和有效行走至关重要。本文提出的假设是，在坐骨神经周围放置扁平接口神经电极（FINE），在预定位置固定接触数，并且无需事先了解神经底层的神经解剖结构即可选择性地控制每个踝关节运动。创建了由大小不同的FINE围绕的人坐骨神经模型，并将其用于计算在任意指定的连续束丛中轴突选择性激活的可能性。模拟支持该假设，并表明当前可用的可植入技术不能选择性地单独募集每个目标plant屈，但可以从坐骨神经上的部位恢复restore屈或背屈而不会溢出到拮抗剂上。通过使用双极刺激和/或使用具有至少20个接触点的袖带，可以成功地激活90％人口的单个脚踝肌肉。

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  • 来源
    《Journal of Computational Neuroscience》 |2012年第1期|p.179-190|共12页
  • 作者

    Matthew A. Schiefer; Dustin J. Tyler; Ronald J. Triolo;

  • 作者单位

    Department of Biomedical Engineering,Case Western Reserve University (CWRU),10900 Euclid Ave,Cleveland, OH 44106, USA,Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC),151 AW/APT, 10701 EastBlvd,Cleveland, OH 44106, USA;

    Department of Biomedical Engineering,Case Western Reserve University (CWRU),10900 Euclid Ave,Cleveland, OH 44106, USA,Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC),151 AW/APT, 10701 EastBlvd,Cleveland, OH 44106, USA;

    Department of Biomedical Engineering,Case Western Reserve University (CWRU),10900 Euclid Ave,Cleveland, OH 44106, USA,Louis Stokes Cleveland Department of Veterans Affairs Medical Center (LSCDVAMC),151 AW/APT, 10701 EastBlvd,Cleveland, OH 44106, USA,Department of Orthopaedics,Case Western Reserve University (CWRU),10900 Euclid Ave,Cleveland, OH 44106, USA;

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  • 正文语种 eng
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  • 关键词

    sciatic nerve; flat interface nerve electrode(FINE); functional electrical stimulation (FES); three dimensional finite element method (3D FEM); selective stimulation;

    机译：坐骨神经扁平界面神经电极（FINE）;功能性电刺激（FES）;三维有限元方法（3D FEM）;选择性刺激;

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