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首页> 外文期刊>Journal of Computational Neuroscience >Interplay of the magnitude and time-course of postsynaptic Ca~(2+) concentration in producing spike timing-dependent plasticity
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Interplay of the magnitude and time-course of postsynaptic Ca~(2+) concentration in producing spike timing-dependent plasticity

机译：突触后钙〜（2+）浓度的大小和时程在产生峰值时序相关可塑性中的相互作用

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Synaptic strength can be modified by the relative timing of pre- and postsynaptic activity, a phenomenon termed spike timing-dependent plasticity (STDP). Studies of neurons in the hippocampus and in other regions have found that when presynaptic activity occurs within a narrow time window, typically 10 or 20 ms, before postsynaptic activity, long-term potentiation (LTP) is induced, while if presynaptic activity occurs within a similar time window after postsynaptic activity, long-term depression (LTD) results. The mechanisms underlying these modifications are not completely understood, although there is strong evidence that the postsynaptic Ca~(2+) concentration plays a central role. Some previous modeling of STDP has focused on the dynamics of the postsynaptic Ca~(2+) concentration, while other work has studied biophysical mechanisms of how a synapse can exist in, and switch between, different states corresponding to LTP and LTD. Building on previous work in these two areas we have developed the first low level STDP model of a tristable biochemical system that incorporates induction and maintenance of both LTP and LTD. Our model is able to explain the STDP observed in hip-pocampal neurons in response to pre- and postsynaptic pulse pairs, using only parameters derived from previous work and without the need for parameter fine-tuning. Our results also give insight into how and why the time course of the postsynaptic Ca~(2+) concentration can lead to either LTP or LTD, and suggest that voltage dependent calcium channels play a key role.
机译：突触强度可以通过突触前和突触后活动的相对时机进行修改，这种现象称为尖峰时机依赖性塑性（STDP）。对海马和其他区域神经元的研究发现，当突触前​​活动在狭窄的时间窗口（通常为10或20毫秒）内发生时，在突触后活动之前，会诱导长期增强（LTP），而如果突触前活动发生在神经突触内。突触后活动后相似的时间窗口，导致长期抑郁（LTD）。尽管有充分的证据表明突触后Ca〜（2+）的浓度起着重要作用，但尚未完全理解这些修饰的机制。 STDP先前的一些模型集中于突触后Ca〜（2+）浓度的动态变化，而其他工作则研究了突触如何存在于LTP和LTD对应的不同状态并在不同状态之间切换的生物物理机制。在这两个领域的先前工作的基础上，我们开发了三稳态生化系统的第一个低级STDP模型，该模型结合了LTP和LTD的诱导和维持。我们的模型能够解释突触前和突触后脉冲对在海马神经元中观察到的STDP，仅使用从先前工作得出的参数，而无需进行参数微调。我们的研究结果还揭示了突触后Ca〜（2+）浓度的时间过程如何以及为何会导致LTP或LTD的见解，并暗示电压依赖性钙通道起着关键作用。

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