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首页> 外文期刊>Cerebral cortex >Input Specificity and Dependence of Spike Timing-Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells
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Input Specificity and Dependence of Spike Timing-Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells

机译：输入特异性和穗时间依赖性可塑性对前皮层突触后活动在新皮层2/3金字塔形细胞之间的单一连接的依赖。

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Layer 2/3 (L2/3) pyramidal cells receive excitatory afferent input both from neighbouring pyramidal cells and from cortical and subcortical regions. The efficacy of these excitatory synaptic inputs is modulated by spike timing-dependent plasticity (STDP). Here we report that synaptic connections between L2/3 pyramidal cell pairs are located proximal to the soma, at sites overlapping those of excitatory inputs from other cortical layers. Nevertheless, STDP at L2/3 pyramidal to pyramidal cell connections showed fundamental differences from known STDP rules at these neighbouring contacts. Coincident low-frequency pre- and postsynaptic activation evoked only LTD, independent of the order of the pre- and postsynaptic cell firing. This symmetric anti-Hebbian STDP switched to a typical Hebbian learning rule if a postsynaptic action potential train occurred prior to the presynaptic stimulation. Receptor dependence of LTD and LTP induction and their pre- or postsynaptic loci also differed from those at other L2/3 pyramidal cell excitatory inputs. Overall, we demonstrate a novel means to switch between STDP rules dependent on the history of postsynaptic activity. We also highlight differences in STDP at excitatory synapses onto L2/3 pyramidal cells which allow for input specific modulation of synaptic gain.
机译：第2/3（L2 / 3）层锥体细胞从邻近的锥体细胞以及皮质和皮质下区域接受兴奋性传入输入。这些兴奋性突触输入的功效是由峰值时间相关可塑性（STDP）调节的。在这里我们报告说，L2 / 3锥体细胞对之间的突触连接位于躯体的近端，位于与其他皮质层的兴奋性输入重叠的位置。然而，L2 / 3锥体细胞到锥体细胞连接处的STDP显示出与这些相邻接触处的已知STDP规则的根本区别。巧合的低频突触前和突触后激活仅诱发LTD，与突触前和突触后细胞激发的顺序无关。如果在突触前刺激之前发生了突触后动作电位训练，则此对称的反希伯来STDP会切换到典型的Hebbian学习规则。 LTD和LTP诱导及其突触前或突触后基因座的受体依赖性也不同于其他L2 / 3锥体细胞兴奋性输入。总体而言，我们展示了一种新颖的手段，可根据突触后活动的历史在STDP规则之间进行切换。我们还强调了STDP在L2 / 3锥体细胞兴奋性突触上的差异，这允许输入特定的突触增益调节。

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