...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Computational Neuroscience >Interacting oscillations in neural control of breathing:modeling and qualitative analysis
【24h】

Interacting oscillations in neural control of breathing:modeling and qualitative analysis

机译：呼吸神经控制中的相互作用振荡：建模和定性分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In mammalian respiration, late-expiratory (late-E, or pre-inspiratory) oscillations emerge in abdominal motor output with increasing metabolic demands (e.g., during hypercapnia, hypoxia, etc.). These oscillations originate in the retrotrapezoid nucleus/parafacial respiratory group (RTN/ pFRG) and couple with the respiratory oscillations generated by the interacting neural populations of the Botzinger (BotC) and pre-Boetzinger (pre-BoetC) complexes, representing the kernel of the respiratory central pattern generator. Recently, we analyzed experimental data on the generation of late-E oscillations and proposed a large-scale computational model that simulates the possible interactions between the BotC/pre-BotC and RTN/pFRG oscillations under different conditions. Here we describe a reduced model that maintains the essential features and architecture of the large-scale model, but relies on simplified activity-based descriptions of neural populations. This simplification allowed us to use methods of dynamical systems theory, such as fast-slow decomposition, bifurcation analysis, and phase plane analysis, to elucidate the mechanisms and dynamics of synchronization between the RTN/pFRG and BoetC/pre-BoetC oscillations. Three physiologically relevant behaviors have been analyzed: emergence and quantal acceleration of late-E oscillations during hypercapnia, transformation of the late-E activity into a biphasic-E activity during hypercapnic hypoxia, and quantal slowing of BotC/pre-BotC oscillations with the reduction of pre-BoetC excitability. Each behavior is elicited by gradual changes in excitatory drives or other model parameters, reflecting specific changes in metabolic and/or physiological conditions. Our results provide important theoretical insights into interactions between RTN/pFRG and BoetC/pre-BoetC oscillations and the role of these interactions in the control of breathing under different metabolic conditions.
机译：在哺乳动物的呼吸中，随着新陈代谢需求的增加（例如，在高碳酸血症，低氧等期间），腹部运动输出中会出现呼气晚期（晚期E或吸气前）振荡。这些振荡起源于梯形后核/面呼吸组（RTN / pFRG），并与由Botzinger（BotC）和Boetzinger前体（pre-BoetC）复合体相互作用的神经群体产生的呼吸振荡相耦合，代表了核的核心。呼吸中枢模式发生器。最近，我们分析了关于后期E振荡产生的实验数据，并提出了一个大型计算模型，该模型模拟了在不同条件下BotC / pre-BotC和RTN / pFRG振荡之间的可能相互作用。在这里，我们描述了一个简化的模型，该模型保留了大规模模型的基本特征和体系结构，但是依赖于基于简化的基于活动的神经种群描述。这种简化使我们能够使用动力学系统理论的方法，例如快速慢速分解，分叉分析和相平面分析，来阐明RTN / pFRG与BoetC / pre-BoetC振荡之间的同步机理和动力学。分析了三种与生理相关的行为：高碳酸血症期间晚期E振荡的出现和数量加速，高碳酸血症低氧期间晚期E活性转变为双相E活性以及BotC / BotC振荡的定量减慢与降低BoetC之前的兴奋性。每种行为都是由兴奋性驱动力或其他模型参数的逐渐变化引起的，反映了代谢和/或生理状况的特定变化。我们的研究结果为RTN / pFRG与BoetC / pre-BoetC振荡之间的相互作用以及这些相互作用在不同代谢条件下控制呼吸中的作用提供了重要的理论见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号