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首页> 外文期刊>Journal of Computational Neuroscience >Conflicting effects of excitatory synaptic and electric coupling on the dynamics of square-wave bursters
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Conflicting effects of excitatory synaptic and electric coupling on the dynamics of square-wave bursters

机译:兴奋性突触和电耦合对方波爆发器动力学的影响

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摘要

Using two-cell and 50-cell networks of square-wave bursters, we studied how excitatory coupling of individual neurons affects the bursting output of the network. Our results show that the effects of synaptic excitation vs. electrical coupling are distinct. Increasing excitatory synaptic coupling generally increases burst duration. Electrical coupling also increases burst duration for low to moderate values, but at sufficiently strong values promotes a switch to highly synchronous bursts where further increases in electrical or synaptic coupling have a minimal effect on burst duration. These effects are largely mediated by spike synchrony, which is determined by the stability of the in-phase spiking solution during the burst. Even when both coupling mechanisms are strong, one form (in-phase or anti-phase) of spike synchrony will determine the burst dynamics, resulting in a sharp boundary in the space of the coupling parameters. This boundary exists in both two cell and network simulations. We use these results to interpret the effects of gap-junction blockers on the neuronal circuitry that underlies respiration.
机译:使用方波猝发器的两个单元和50个单元的网络,我们研究了单个神经元的兴奋性耦合如何影响网络的猝发输出。我们的结果表明,突触激发与电耦合的影响是不同的。增加兴奋性突触耦合通常会增加爆发持续时间。对于低到中等值,电耦合也会增加突发持续时间,但是在足够强的值时,会促使切换到高度同步的突发,其中电或突触耦合的进一步增加对突发持续时间的影响最小。这些影响主要由尖峰同步引起,尖峰同步由突发期间同相尖峰解决方案的稳定性决定。即使当两个耦合机制都很强时,尖峰同步的一种形式(同相或反相)也将确定突发动态,从而在耦合参数的空间中产生清晰的边界。在两个单元和网络仿真中都存在此边界。我们用这些结果来解释间隙连接阻滞剂对作为呼吸基础的神经元回路的影响。

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  • 来源
    《Journal of Computational Neuroscience》 |2011年第3期|p.701-711|共11页
  • 作者单位

    Laboratory for Neuroengineering, Georgia Institute of Technology, Mailstop 0250, Atlanta, GA 30332-0250 USA,Dept. of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA,School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA;

    Laboratory for Neuroengineering, Georgia Institute of Technology, Mailstop 0250, Atlanta, GA 30332-0250 USA,Interdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, Atlanta, GA, USA,Dept. of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA;

    Laboratory for Neuroengineering, Georgia Institute of Technology, Mailstop 0250, Atlanta, GA 30332-0250 USA,Graduate Program in Neuroscience and Department of Biology, Emory University, Atlanta, GA, USA;

    Laboratory for Neuroengineering, Georgia Institute of Technology, Mailstop 0250, Atlanta, GA 30332-0250 USA,Dept. of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA,School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    pacemaker neuron; square-wave bursting; synchronization; bifurcation analysis;

    机译:起搏器神经元方波突发同步分叉分析;

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