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首页> 外文期刊>Journal of Computational Neuroscience >Persistent membranous cross correlations due to the multiplicity of gates in ion channels
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Persistent membranous cross correlations due to the multiplicity of gates in ion channels

机译：由于离子通道中门的多样性，导致了持久的膜互相关

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摘要

Ion channels in excitable cells reveal spontaneous intermittent opening and closing. As the membrane area reduces, this stochasticity enables spontaneous firing and elevates the cell's ability to fire at weaker stimuli. A multiple number of gates are accommodated in each individual ion channel. Here we investigate the possible impact of that gate multiplicity on the cell's function specifically when the membrane area is of limited size. It is shown that a non-trivially persistent correlation then takes place between the transmembrane voltage fluctuations (also between the fluctuations in the gating variables) and the component of open channel fluctuations attributed to the above gate multiplicity. This cross correlation persistency is found to be playing a major augmentative role in the elevation of the cell's excitability and spontaneous firing; without the persistency, the cell would be much less excitable. The cross correlation persistency is also found to enhance spike coherence. The stochastic Hodgkin-Huxley equations, put forward by Fox and Lu, are addressed in the context of their recognized failure to produce accurate enough statistics of spike generation. Our results indicate that the major source of that inaccuracy is the incapability of the stochastic Hodgkin-Huxley description to reflect the above cross correlation persistency.
机译：兴奋性细胞中的离子通道显示出自发的间歇性打开和关闭。随着膜面积的减少，这种随机性可以自发激发，并增强了细胞在较弱刺激下的激发能力。每个单独的离子通道中都装有多个门。在这里，我们研究了门的多重性对细胞功能的可能影响，特别是当膜面积有限时。结果表明，在跨膜电压波动之间（以及在门控变量的波动之间）和归因于上述栅极多重性的明渠波动的分量之间发生了非平凡的持久相关。发现这种相互关联的持久性在细胞兴奋性和自发放电的升高中起着主要的增强作用。没有持久性，细胞的兴奋性将大大降低。还发现互相关持久性增强了尖峰相干性。 Fox和Lu提出的随机Hodgkin-Huxley方程是在公认的无法产生足够的尖峰产生统计量的情况下解决的。我们的结果表明，这种不准确性的主要根源是随机Hodgkin-Huxley描述无法反映上述互相关持久性。

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