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首页> 外文期刊>Journal of Computational Neuroscience >Cross-trial correlation analysis of evoked potentials reveals arousal-related attenuation of thalamo-cortical coupling
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Cross-trial correlation analysis of evoked potentials reveals arousal-related attenuation of thalamo-cortical coupling

机译：诱发电位的交叉试验相关分析揭示了丘脑-皮层耦合的唤醒相关衰减

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摘要

We describe a computational method for assessing functional connectivity in sensory neuronal networks. The method, which we term cross-trial correlation, can be applied to signals representing local field potentials (LFPs) evoked by sensory stimulations and utilizes their trial-to-trial variability. A set of single trial samples of a given post-stimulus latency from consecutive evoked potentials (EPs) recorded at a given site is correlated with such sets for all other latencies and recording sites. The results of this computation reveal how neuronal activities at various sites and latencies correspond to activation of other sites at other latencies. The method was used to investigate the functional connectivity of thalamo-cortical network of somatosensory system in behaving rats at two levels of alertness: habituated and aroused. We analyzed potentials evoked by vibrissal deflections recorded simultaneously from the ventrobasal thalamus and barrel cortex. The cross-trial correlation analysis applied to the early post-stimulus period (<25 ms) showed that the magnitude of the population spike recorded in the thalamus at 5 ms post-stimulus correlated with the cortical activation at 6-13 ms post-stimulus. This correlation value was reduced at 6-9 ms, i.e. at early postsynaptic cortical response, with increased level of the animals' arousal. Similarly, the aroused state diminished positive thalamo-cortical correlation for subsequent early EP waves, whereas the efficacy of an indirect cortico-fugal inhibition (over 15 ms) did not change significantly. Thus we were ablernto characterize the state related changes of functional connections within the thalamo-cortical network of behaving animals.
机译：我们描述了一种评估感觉神经元网络中功能连接性的计算方法。该方法（我们称为交叉试验相关性）可以应用于代表由感官刺激引起的局部场电位（LFP）的信号，并利用其试验间的可变性。来自在给定部位记录的连续诱发电位（EP）的给定刺激后潜伏期的一组单次试验样本与所有其他潜伏期和记录部位的此类样本集相关。该计算的结果揭示了在各个部位和潜伏期的神经元活动如何对应于在其他潜伏期的其他部位的激活。该方法用于研究行为习惯的大鼠的皮层丘脑-皮质网络在功能上的警觉性和引起警觉性两种水平。我们分析了由室基底丘脑和桶状皮层同时记录的震颤偏转引起的电位。应用于刺激后早期（<25 ms）的交叉试验相关性分析表明，刺激后5 ms丘脑中记录的种群突增幅度与刺激后6-13 ms的皮质激活相关。在6-9毫秒（即在突触后早期皮质反应中），随着动物唤醒水平的提高，这种相关性值降低。同样，在随后的早期EP波中，唤醒状态减弱了丘脑-皮质相关性，而间接皮质-真菌抑制作用（超过15毫秒）的疗效没有明显改变。因此，我们能够表征行为动物丘脑-皮质网络中功能连接的状态相关变化。

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  • 来源
    《Journal of Computational Neuroscience》 |2010年第3期|p.485-493|共9页
  • 作者

    Aleksander Sobolewski; Ewa Kublik; Daniel A. Swiejkowski; Szymon Leski; Jan K. Kaminski; Andrzej Wrobel;

  • 作者单位

    Nencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

    rnNencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

    rnNencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

    rnNencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

    rnNencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

    rnNencki Institute of Experimental Biology-Polish Academy of Sciences,3 Pasteur St., 02-093 Warsaw, Poland;

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  • 正文语种 eng
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  • 关键词

    LFP; awake rat; vibrissae-barrel system; functional connectivity;

    机译：LFP;清醒的老鼠振动桶系统;功能连接;

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