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首页> 外文期刊>Journal of Computational Neuroscience >Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons
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Modelling and sensitivity analysis of the reactions involving receptor, G-protein and effector in vertebrate olfactory receptor neurons

机译：脊椎动物嗅觉受体神经元中涉及受体，G蛋白和效应子的反应的建模和敏感性分析

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A biochemical model of the receptor, G-protein and effector (RGE) interactions during transduction in the cilia of vertebrate olfactory receptor neurons (ORNs) was developed and calibrated to experimental recordings of cAMP levels and the receptor current (RC). The model describes the steps from odorant binding to activation of the effector enzyme which catalyzes the conversion of ATP to cAMP, and shows how odorant stimulation is amplified and delayed by the RGE transduction cascade. A time-dependent sensitivity analysis was performed on the model. The model output-the cAMP production rate-is particularly sensitive to a few, dominant parameters. During odorant stimulation it depends mainly on the initial density of G-proteins and the catalytic constant for cAMP production.
机译：建立了脊椎动物嗅觉受体神经元（ORNs）纤毛转导过程中受体，G蛋白和效应物（RGE）相互作用的生化模型，并根据cAMP水平和受体电流（RC）的实验记录进行了校准。该模型描述了从加味剂结合到催化ATP转化为cAMP的效应酶激活的步骤，并显示了RGE转导级联如何放大和延迟加味剂刺激。对模型进行了随时间变化的敏感性分析。模型输出-cAMP生产率-对一些主要参数特别敏感。在加味剂刺激过程中，它主要取决于G蛋白的初始密度和cAMP产生的催化常数。

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