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首页> 外文期刊>Journal of Computational Neuroscience >Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture
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Simulation system of spinal cord motor nuclei and associated nerves and muscles, in a Web-based architecture

机译：基于Web的体系结构中的脊髓运动核以及相关神经和肌肉的仿真系统

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A Web-based simulation system of the spinal cord circuitry responsible for muscle control is described. The simulator employs two-compartment motoneuron models for S, FR and FF types, with synaptic inputs acting through conductance variations. Four motoneuron pools with their associated interneurons are represented in the simulator, with the possibility of inclusion of more than 2,000 neurons and 2,000,000 synapses. Each motoneuron action potential is followed, after a conduction delay, by a motor unit potential and a motor unit twitch. The sums of all motor unit potentials and twitches result in the electromyogram (EMG), and the muscle force, respectively. Inputs to the motoneuron pool come from populations of interneurons (Ia reciprocal inhibitory interneurons, Ib interneurons, and Renshaw cells) and from stochastic point processes associated with descending tracts. To simulate human electrophysiological experiments, the simulator incorporates external nerve stimulation with orthodromic and antidromic propagation. This provides the mechanisms for reflex generation and activation of spinal neuronal circuits that modulate the activity of another motoneuron pool (e.g., by reciprocal inhibition). The generation of the H-reflex by the Ia-motoneuron pool system and its modulation by spinal cord interneurons is included in the simulation system. Studies with the simulator may include the statistics of individual motoneuron or interneuron spike trains or the collective effect of a motor nucleus on the dynamics of muscle force control. Properties associated with motor-unit recruitment, motor-unit synchronization, recurrent inhibition and reciprocal inhibition may be investigated.
机译：描述了负责肌肉控制的脊髓电路的基于Web的仿真系统。该模拟器针对S，FR和FF类型采用两室运动神经元模型，其突触输入通过电导变化来起作用。模拟器中代表了四个运动神经元池及其相关的中间神经元，其中可能包含2000多个神经元和2000000个突触。在传导延迟之后，每个运动神经元动作电位都跟随一个电机单元电位和一个电机单元抽搐。所有运动单位电位和抽动的总和分别产生肌电图（EMG）和肌肉力。运动神经元池的输入来自中间神经元（Ia相互抑制的中间神经元，Ib中间神经元和Renshaw细胞）的种群，以及来自与下降线相关的随机点过程。为了模拟人体电生理实验，该模拟器将外部神经刺激与矫正和反矫正传播相结合。这提供了反射产生和激活脊髓神经元回路的机制，其调节另一个运动神经元池的活性（例如，通过相互抑制）。 Ia-运动神经元池系统产生的H-反射及其通过脊髓中神经元进行的调制都包含在模拟系统中。用模拟器进行的研究可能包括单个运动神经元或中间神经元尖峰序列的统计信息，或者运动核对肌肉力控制动力学的集体影响。可以研究与运动单位募集，运动单位同步，递归抑制和相互抑制相关的特性。

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