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首页> 外文期刊>Journal of Computational Neuroscience >How do glutamatergic and GABAergic cells contribute to synchronization in the medial septum?
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How do glutamatergic and GABAergic cells contribute to synchronization in the medial septum?

机译：谷氨酸能和GABA能细胞如何促进内侧间隔的同步化？

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The medial septum-diagonal band (MSDB) complex is considered as a pacemaker for the hippocampal theta rhythm. Identification of the different cell types, their electro-physiological properties and their possible function in the generation of a synchronized activity in the MSDB is a hot topic. A recent electro-physiological study showed the presence of two antiphasically firing populations of parvalbumin containing GABAergic neurons in the MSDB. Other papers described a network of cluster-firing glutamatergic neurons, which is able to generate synchronized activity in the MSDB. We propose two different computer models for the generation of synchronized population theta oscillation in the MSDB and compare their properties. In the first model GABAergic neurons are intrinsically theta periodic cluster-firing cells; while in the second model GABAergic cells are fast-firing cells and receive periodic input from local glutamatergic neurons simulated as cluster-firing cells. Using computer simulations we show that the GABAergic neurons in both models are capable of generating antiphasic theta periodic population oscillation relying on local, septal mechanisms. In the first model antiphasic theta synchrony could emerge if GABAergic neurons form two populations preferentially innervate each other. In the second model in-phase synchronization of glutamatergic neurons does not require specific network structure, and the network of these cells are able to act as a theta pacemaker for the local fast-firing GABAergic circuit. Our simulations also suggest that neurons being non-cluster-firing in vitro might exhibit clustering properties when connected into a network in vivo.
机译：内侧中隔对角带（MSDB）复合体被认为是海马θ节律的起搏器。鉴定不同细胞类型，其电生理特性及其在MSDB中同步活动产生中的可能功能是一个热门话题。最近的一项电生理研究表明，MSDB中存在两个反相激发的含有GABA能神经元的小白蛋白种群。其他论文描述了簇状发射的谷氨酸能神经元网络，该网络能够在MSDB中产生同步活动。我们提出了两种不同的计算机模型，用于在MSDB中生成同步的人口theta振荡，并比较它们的特性。在第一个模型中，GABA能神经元本质上是周期性周期性聚集的细胞。而在第二种模型中，GABA能细胞是速发细胞，并从模拟为簇发细胞的局部谷氨酸能神经元接收周期性输入。使用计算机模拟，我们表明两种模型中的GABA能神经元都能够依靠局部，间隔机制来产生反相位theta周期性种群振荡。在第一个模型中，如果形成GABA能神经元的两个种群优先相互支配，则反相位theta同步可能出现。在第二种模型中，谷氨酸能神经元的同相同步不需要特定的网络结构，并且这些细胞的网络能够充当局部快速发射GABA能电路的theta起搏器。我们的模拟还表明，在体外非聚集放电的神经元在连接到体内网络时可能表现出聚集特性。

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