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首页> 外文期刊>Journal of Computational Neuroscience >Computational Study of Enhanced Excitability in Hermissenda: Membrane Conductances Modulated by 5-HT
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Computational Study of Enhanced Excitability in Hermissenda: Membrane Conductances Modulated by 5-HT

机译：Hermissenda中增强兴奋性的计算研究：5-HT调节的膜电导

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Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K~+ current (I_(K,A)), sustained Ca~(2+) current (I_(Ca,S), Ca-dependent K~+ current (I_(K,Ca)), and a hyperpolarization-activated inward rectifier current (I_h). In this study, we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. Ion currents were systematically varied within limits observed experimentally, both individually and in combinations. A reduction of I_(K, A) or I_(K,Ca) or an increase in I_h enhanced excitability by 20-50%. Decreasing I_(Ca, S) produced a dramatic decrease in excitability. Reductions of I_(K,V) produced only minimal increases in excitability, suggesting that I_(K,V) probably plays a minor role in 5-HT induced enhanced excitability. Combinations of changes in I_(K,A), I_(K,Ca), I_h and I_(Ca, S) produced increases in excitability comparable to experimental observations. After 5-HT application, the cell's depolarization force is shifted from the I_h-I_(Ca,S) combination to predominantly I_h.
机译：将5-羟色胺（5-HT）应用于裸露但完整的神经系统会增强Hermissenda B型感光体的兴奋性。 5-HT调节B型感光体中的几个离子电流，包括A型K〜+电流（I_（K，A）），持续的Ca〜（2+）电流（I_（Ca，S）， Ca依赖的K〜+电流（I_（K，Ca））和超极化激活的内向整流器电流（I_h）。在这项研究中，我们建立了一个计算模型，该模型可再现B型感光体的生理特性，例如静息膜电位，暗适应性刺突活性，刺突宽度以及体细胞突突和轴突突突之间的幅度差，然后我们使用该模型研究5-HT调制的不同离子电流对5-HT产生的增强兴奋性幅度的贡献。离子电流在实验观察到的范围内（无论是单独还是组合）都在系统范围内变化，I_（K，A）或I_（K，Ca）的减少或I_h的增加会增强20-50％的兴奋性。 S）导致兴奋性急剧下降，I_（K，V）的减小仅使兴奋性增加，表明I_（K，V）可能在5-HT诱导的兴奋性增强中起次要作用。与实验观察结果相比，I_（K，A），I_（K，Ca），I_h和I_（Ca，S）的变化组合产生的兴奋性增加。施加5-HT后，细胞的去极化力从I_h-I_（Ca，S）组合转移到I_h为主。

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