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首页> 外文期刊>Journal of Crystal Growth >Detection of the II—I Etiracetam solvent-mediated polymorphic transformation through the online monitoring of the suspension apparent viscosity
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Detection of the II—I Etiracetam solvent-mediated polymorphic transformation through the online monitoring of the suspension apparent viscosity

机译：通过在线监测悬浮液表观粘度来检测II-I阿替西坦溶剂介导的多态性转化

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摘要

Although going to complex techniques can be useful at some stage of process development of crystallization processes, the goal of this article is to show that process control can also be achieved with relatively simple measurements, depending of course on what type of control is needed. Focusing on the Etiracetam crystallization process, this work demonstrates the potential of the online monitoring of the power dissipated in the suspension, a property that can be directly related to the suspension apparent viscosity for the detection of the solvent-mediated polymorphic transformation from form II to form I. Even if the work presented in this paper focused on a specific crystallization process, this easy-to-use method seems promising for the control of other crystallization processes exhibiting solvent-mediated polymorphic transformations with similar characteristics: (i) significant difference in the PSD of the crystals of the stable and the metastable forms, (ii) solid volumetric fraction in the suspension higher than 40% and (iii) absence of phenomena (breaking, attrition, agglomeration, secondary nucleation, etc.) interfering with the polymorphic transformation and affecting the PSD of the crystals.
机译：尽管使用复杂的技术在结晶过程的过程开发的某些阶段可能会有用，但本文的目的是表明还可以通过相对简单的测量来实现过程控制，具体取决于所需的控制类型。着眼于艾替西坦的结晶过程，这项工作证明了在线监测悬浮液中耗散功率的潜力，该特性可以直接与悬浮液的表观粘度相关，以检测溶剂介导的从晶型II到晶型的转变。即使本文中介绍的工作集中在特定的结晶过程上，这种易于使用的方法似乎也有望用于控制其他表现出具有类似特征的溶剂介导的多晶型转变的结晶过程：（i）显着不同稳定和亚稳形式的晶体的PSD，（ii）悬浮液中的固体体积分数高于40％，以及（iii）没有干扰多态性的现象（破裂，磨损，团聚，二次成核等）转变并影响晶体的PSD。

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  • 来源
    《Journal of Crystal Growth》 |2012年第1期|p.57-64|共8页
  • 作者

    Christelle Herman; Tom Leyssens; Frederic Debaste; Benoit Haut;

  • 作者单位

    Universite Libre de Bruxelles, Transfers, Interfaces and Processes Department, Chemical Engineering Unit, 50 Avenue Franklin D-Roosevelt, CP 165/67, 1050 Brwcelles, Belgium;

    Universite Catholique de Louvain, Institute of Condensed Matter and Nanosciences, 1 Place Louis Pasteur, 1348 Louvain-La-Neuve, Belgium;

    Universite Libre de Bruxelles, Transfers, Interfaces and Processes Department, Chemical Engineering Unit, 50 Avenue Franklin D-Roosevelt, CP 165/67, 1050 Brwcelles, Belgium;

    Universite Libre de Bruxelles, Transfers, Interfaces and Processes Department, Chemical Engineering Unit, 50 Avenue Franklin D-Roosevelt, CP 165/67, 1050 Brwcelles, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    A1. industriA1 crystA1lization; A1. crystA1s characterization; A1. Apparent viscosity; B3. Solid state; B3. Metzner and otto concept;

    机译：A1。工业化结晶;A1。 crystA1s表征;A1。表观粘度;B3。固体状态;B3。梅茨纳和奥托的概念;

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