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首页> 外文期刊>Journal of Crystal Growth >Solubility, inhibition of crystallization and microscopic analysis of calcium oxalate crystals in the presence of fractions from Humulus lupulus L.
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Solubility, inhibition of crystallization and microscopic analysis of calcium oxalate crystals in the presence of fractions from Humulus lupulus L.

机译:草屑部分存在下草酸钙晶体的溶解度,结晶抑制作用和显微分析。

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摘要

Procedures for obtaining noncytotoxic and nonmutagenic extracts from Humulus lupulus L of high potency for inhibition and dissolving of model (calcium oxalate crystals) and real kidney stones, obtained from patients after surgery, are presented. Multistep extraction procedures were performed in order to obtain the preparations with the highest calcium complexing properties. The composition of obtained active fractions was analyzed by GC/MS and NMR methods. The influence of preparations on inhibition of formation and dissolution of model and real kidney stones were evaluated based on conductrometric titration, flame photometry and microscopic analysis. The "fraction soluble in methanol" obtained from water-alkaline extracts contains sugar alcohols and organic acids, and is effective in dissolving the kidney stones. The "fraction insoluble in methanol" contains only sugar derivatives and it changes the morphology of the crystals, making them "jelly-like". Both fractions are potentially effective in kidney stone therapy.
机译:提出了从得自手术后的患者的高效抑制和溶解模型(草酸钙晶体)和真实肾结石的Hum草中获得非细胞毒性和非致突变性提取物的方法。为了获得具有最高钙络合性能的制剂,进行了多步提取程序。通过GC / MS和NMR方法分析获得的活性级分的组成。基于电导滴定,火焰光度法和显微镜分析,评估了制剂对抑制模型和真实肾结石形成和溶解的影响。由水-碱提取物得到的“溶于甲醇的馏分”含有糖醇和有机酸,对溶解肾结石有效。 “不溶于甲醇的馏分”仅包含糖衍生物,它改变了晶体的形态,使它们“呈果冻状”。两种成分均可能在肾结石治疗中有效。

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