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首页> 外文期刊>Journal of dairy research >Liver X receptor a participates in LPS-induced reduction of triglyceride synthesis in bovine mammary epithelial cells
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Liver X receptor a participates in LPS-induced reduction of triglyceride synthesis in bovine mammary epithelial cells

机译：肝X受体A参与牛乳腺上皮细胞中甘油三酯合成的LPS诱导的降低

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摘要

Lipopolysaccharides (LPS) could induce milk fat depression via regulating the body and blood fat metabolism. However, it is not completely clear how LPS might regulate triglyceride synthesis in dairy cow mammary epithelial cells (DCMECs). DCMECs were isolated and purified from dairy cow mammary tissue and treated with LPS. The level of triglyceride synthesis, the expression and activity of the liver X receptor α (LXRα), enzymes related to de novo fatty acid synthesis, and the expression of the fatty acid transporters were investigated. We found that LPS decreased the level of triglyceride synthesis via a down-regulation of the transcription, translation, and nuclear translocation level of the LXRα. The results also indicated that the transcription level of the LXRa target genes, sterol regulatory element binding protein 1 (SREBP1), fatty acid synthetase (FAS), acetyl-CoA carboxylase-1 (ACC1), were significantly down-regulated in DCMECs after LPS treatment. Our data may provide new insight into the mechanisms of milk fat depression caused by LPS.
机译：脂多糖（LPS）可通过调节身体和血脂代谢来诱导乳脂抑郁症。然而，它不完全清楚LPS如何调节乳制牛乳腺上皮细胞（DCMEC）中的甘油三酯合成。分离和纯化DCMECs从奶牛乳腺组织中纯化并用LPS处理。研究了甘油三酯合成的水平，肝X受体α（LXRα）的表达和活性，与Novo脂肪酸合成有关的酶，以及脂肪酸转运蛋白的表达。我们发现LPS通过降低LXRα的转录，翻译和核转位水平来降低甘油三酯合成水平。结果还表明，LPS后，LXRA靶基因，甾醇调节元件结合蛋白1（SrebP1），脂肪酸合成酶（Fas），乙酰-CoA羧化酶-1（ACC1）的转录水平在DCMEC中显着下调治疗。我们的数据可能会对LPS引起的乳脂抑郁机制提供新的洞察力。

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  • 来源
    《Journal of dairy research》 |2020年第4期|456-462|共7页
  • 作者

    Jianfa Wang; Shuai Lian; Jun Song; Hai Wang; Xu Zhang; Xianjing He; Dandan Hao; Rui Wu;

  • 作者单位

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

    College of Animal Science and Veterinary Medicine Heilongjiang Bayi Agricultural University No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China Heilongjiang Provincial Key Laboratory of Prevention and Control of Bovine Diseases No. 2 Xinyang Road Sartu District Daqing 163319 P.R. China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    bovine mammary epithelial cells; lipopolysaccharides; liver X receptor a; triglyceride;

    机译：牛乳腺上皮细胞;脂多糖;肝X受体a;甘油三酯;

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