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AGPAT3 Gene polymorphisms are associated with milk production traits in Chinese Holstein cows

机译:AGPAT3基因多态性与中国荷斯坦奶牛的牛奶生产性质有关

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摘要

The current study reports the identification of previously undiscovered single-nucleotide polymorphisms (SNPs) in the bovine AGPAT3 gene and further investigates their associations with milk production traits. Our results demonstrate that the major allele C of the SNP g,12264 C>T is positively correlated with test-day milk yield, protein percentage and 305-day milk yield. Importantly, in silico analysis showed that the C/T transition at this locus gives rise to two new transcription factor binding sites (TFBS), E2F1 and Nkx3-2. Polymorphism g. 18658 G > A was the only SNP associated with milk urea nitrogen (MUN) with the G allele related to an increase in milk urea nitrogen as well as fat percentage. The GG genotype of SNP g.28731 A > G was associated with the highest fat and protein percentage and lowest 305-day milk yield and somatic cell score (SCS). The association between AGPAT3 locus and milk production traits could be utilized in marker-assisted selection for the genetic improvement of milk production traits and, probably in conjunction with other traits, for selection to improve fitness of dairy cattle.
机译:目前的研究报告了牛AGPAT3基因中以前未被发现的单核苷酸多态性(SNP)的鉴定,并进一步调查其与乳产生特征的关联。我们的研究结果表明,SNP G,12264 C> T的主要等位基因C与试日乳屈服,蛋白质百分比和305天的奶产率正相关。重要的是,在硅的分析中,在该基因座的C / T转变产生了两个新的转录因子结合位点(TFB),E2F1和NKX3-2。多态性g。 18658 g> A是唯一与牛奶尿素氮(MUN)相关的SNP,与牛奶尿素氮的增加以及脂肪百分比有关的G等位基因。 SNP G.28731 A> G的GG基因型与最高的脂肪和蛋白质百分比和最低305天的奶产率和体细胞分数(SCS)相关。 AGPAT3基因座和牛奶生产性质之间的关联可用于标记辅助选择以进行牛奶生产性状的遗传改善,并且可能与其他特征相结合,以改善奶牛的适应性。

著录项

  • 来源
    《Journal of dairy research》 |2021年第3期|247-252|共6页
  • 作者单位

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China;

    College of Animal Science and Technology Shandong Agricultural University Taian 271018 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou University Yangzhou 225009 China;

    Key Laboratory of Animal Genetics & Breeding and Molecular Design of Jiangsu Province Yangzhou University Yangzhou 225009 China Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China Yangzhou University Yangzhou 225009 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    1-acylglycerol-3-phosphate O-acyltransferase 3; Association; Dairy cattle; Milk production traits; Single nucleotide polymorphisms;

    机译:1-酰基甘油-3-磷酸O-酰基转移酶3;协会;乳牛;牛奶生产性状;单核苷酸多态性;

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