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首页> 外文期刊>Journal of dairy research >Going further post-RNA-seq: In silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle
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Going further post-RNA-seq: In silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle

机译：进一步的RNA-SEQ：在硅功能分析中，揭示候选基因和与乳房牛乳腺炎有关的调节元件

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This study aimed to obtain a better understanding of the regulatory genes and molecules involved in the development of mastitis. For this purpose, the transcription factors (TF) and MicroRNAs (miRNA) related to differentially expressed genes previously found in extra-corporeal udders infected with Streptococcus agalactiae were investigated. The Gene-TF network highlighted LOC515333, SAA3, CD14, NFKBIA, AP0C2 and LOC100335608 and genes that encode the most representative transcription factors STAT3, PPARG, EGR1 and NFKB1 for infected udders. In addition, it was possible to highlight, through the analysis of the gene-miRNA network, genes that could be post-transcriptionally regulated by miRNAs, such as the relationship between the CCL5 gene and the miRNA bta-miR-363. Overall, our data demonstrated genes and regulatory elements (TF and miRNA) that can play an important role in mastitis resistance. The results provide new insights into the first functional pathways and the network of genes that orchestrate the innate immune responses to infection by Streptococcus agalactiae. Our results will increase the general knowledge about the gene networks, transcription factors and miRNAs involved in fighting intramammary infection and maintaining tissue during infection and thus enable a better understanding of the pathophysiology of mastitis.
机译：本研究旨在更好地了解涉及乳腺炎发展的调节基因和分子。为此目的，研究了与差异表达基因相关的转录因子（TF）和MicroRNA（miRNA）以前在感染链球菌嗜症症的额外嗜毒剂中发现的差异表达基因。基因-TF网络突出显示的LOM515333，SAA3，CD14，NFKBIA，AP0C2和LOC100335608和编码最具代表性转录因子Stat3，PPARG，EGR1和NFKB1的基因，用于感染的uDDERS。此外，通过分析基因 - miRNA网络，可以通过MiRNA分析的基因突出，例如CCL5基因与miRNA BTA-miR-363之间的关系。总体而言，我们的数据显示出基因和调节元素（TF和miRNA），可以在乳腺炎抵抗中发挥重要作用。结果为第一功能途径和基因网络提供了新的洞察，以通过链球菌嗜碱剂协调生物免疫应对感染的先天免疫应答。我们的结果将增加关于在感染期间抗击嵌入型感染和维持组织的基因网络，转录因子和miRNA的一般知识，从而能够更好地了解乳腺炎的病理生理学。

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