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首页> 外文期刊>Journal of dairy research >A novel minimal model to describe non-esterified fatty acid kinetics in Holstein dairy cows
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A novel minimal model to describe non-esterified fatty acid kinetics in Holstein dairy cows

机译：描述荷斯坦奶牛非酯化脂肪酸动力学的新型最小模型

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The dynamics of non-esterified fatty acid (NEFA) metabolism in lactating dairy cows requires quantification if we are to understand how dietary treatments and disease influence changes in body condition (adipose reserves) and the production of milk fat. We present here a novel compartmental model that employs the pattern of plasma glucose concentrations to predict the dynamic changes that occur in plasma NEFA concentrations during an intravenous glucose tolerance test (IVGTT) in lactating dairy cows. The model was developed using data obtained from ten early-lactation, Holstein-Friesian cows given a standard IVCTT. The model described all of the major features of the NEFA response to an IVGTT; it was consistent with physiological processes and provided a number of parameters that can be used to quantify NEFA production and utilization. For all of the individual cows, all model parameters were well identified and usually had CV < 10% of their estimated values. In the model, elevated plasma glucose concentrations cause an increase in the level of glucose in a remote compartment, which in turn suppresses the rate of entry of NEFA to the plasma compartment. The means (±sd) for the five adjustable parameters of the model were: rate of entry of NEFA to the plasma pool (S_(FFA)) 183±71 [μmol l~(-1) min~(-1)], rate of removal (oxidation, sequestration in adipose tissue and uptake by the mammary gland for milk production) of NEFA from the plasma pool (K_(FFA)) 0.140 + 0.047 [min~(-1)], a threshold parameter (g_s) representing a plasma glucose concentration above which elevated levels of plasma glucose result in entry of glucose into a 'remote' or inaccessible glucose compartment, 3.30±0.52 [mmol/l], a rate constant (K) describing the movement of plasma glucose (above g_s) into a remote compartment 0.063±0033 [min~(-1)] and a parameter Φ which is a Michaelis Menten type affinity constant which modulates the extent to which remote glucose inhibits the provision of NEFA to the plasma pool, 0.812±0.276 [mmol/l]. It is concluded that the model is suitable to describe NEFA kinetics in lactating dairy cows and it may have application in other species.
机译：如果我们要了解饮食治疗和疾病如何影响身体状况（脂肪储备）和乳脂生产的变化，则需要对泌乳奶牛中非酯化脂肪酸（NEFA）代谢的动力学进行量化。我们在这里提出一种新颖的隔室模型，该模型采用血浆葡萄糖浓度的模式来预测泌乳奶牛静脉内葡萄糖耐量测试（IVGTT）过程中血浆NEFA浓度的动态变化。该模型是使用从十只早期哺乳期荷斯坦奶牛获得的数据（标准IVCTT）开发的。该模型描述了NEFA对IVGTT反应的所有主要特征。它与生理过程一致，并提供了许多可用于量化NEFA生产和利用的参数。对于所有单独的母牛，所有模型参数都可以很好地识别，并且通常CV <其估计值的10％。在该模型中，血浆葡萄糖浓度升高会导致远端隔室中葡萄糖水平增加，进而抑制NEFA进入血浆室的速率。模型的五个可调参数的平均值（±sd）为：NEFA进入血浆池的速率（S_（FFA））183±71 [μmoll〜（-1）min〜（-1）]，血浆池中NEFA的去除率（氧化，脂肪组织固着和乳腺摄取乳汁）（K_（FFA））0.140 + 0.047 [min〜（-1）]，阈值参数（g_s）代表血浆葡萄糖浓度，高于该浓度时血浆葡萄糖水平升高会导致葡萄糖进入“远程”或无法接近的葡萄糖腔室，3.30±0.52 [mmol / l]，是描述血浆葡萄糖运动的速率常数（K）（以上g_s）进入远端隔室0.063±0033 [min〜（-1）]和参数Φ，它是Michaelis Menten型亲和常数，可调节远端葡萄糖抑制向血浆池提供NEFA的程度，即0.812±0.276 [mmol / l]。结论是该模型适合描述泌乳奶牛的NEFA动力学，并且可能在其他物种中也有应用。

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