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首页> 外文期刊>Journal of dairy science >Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves
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Lactose in milk replacer can partly be replaced by glucose, fructose, or glycerol without affecting insulin sensitivity in veal calves

机译：代乳品中的乳糖可以部分被葡萄糖，果糖或甘油替代，而不会影响小牛的胰岛素敏感性

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摘要

Calf milk replacer (MR) contains 40 to 50% lactose. Lactose strongly fluctuates in price and alternatives are desired. Also, problems with glucose homeostasis and insulin sensitivity (i.e., high incidence of hyperglycemia and hyperinsulinemia) have been described for heavy veal calves (body weight (100 kg). Replacement of lactose by other dietary substrates can be economically attractive, and may also positively (or negatively) affect the risk of developing problems with glucose metabolism. An experiment was designed to study the effects of replacing one third of the dietary lactose by glucose, fructose, or glycerol on glucose homeostasis and insulin sensitivity in veal calves. Forty male Holstein-Friesian (body weight = 114 ± 2.4 kg; age = 97 ± 1.4 d) calves were fed an MR containing 462 g of lactose/kg (CON), or an MR in which 150 g of lactose/kg of MR was replaced by glucose (GLU), fructose (FRU), or glycerol (GLY). During the first 10 d of the trial, all calves received CON. The CON group remained on this diet and the other groups received their experimental diets for a period of 8 wk. Measurements were conducted during the first (baseline) and last week of the trial. A frequently sampled intravenous glucose tolerance test was performed to assess insulin sensitivity and 24 h of urine was collected to measure glucose excretion. During the last week of the trial, a bolus of 1.5 g of [U-~(13)C] substrates was added to their respective meals and plasma glucose, insulin, and ~(13)C-glucose responses were measured. Insulin sensitivity was low at the start of the trial and remained low [1.2 ± 0.1 and 1.0 ± 0.1 (mU/L)~(-1) × min~(-1)], and no treatment effect was noted. Glucose excretion was low at the start of the trial (3.4 ±1.0 g/d), but increased in CON and GLU calves (26.9 ± 3.9 and 43.0 ± 10.6 g/d) but not in FRU and GLY calves. Postprandial glucose was higher in GLU, lower in FRU, and similar in GLY compared with CON calves. Postprandial insulin was lower in FRU and GLY and similar in GLU compared with CON calves. Postprandial ~(13)C-glucose increased substantially in FRU and GLY calves, indicating that calves are able to partially convert these substrates to glucose. We concluded that replacing one third of lactose in MR by glucose, fructose, or glycerol in MR differentially influences postprandial glucose homeostasis but does not affect insulin sensitivity in veal calves.
机译：小牛代乳品（MR）包含40至50％的乳糖。乳糖价格大幅波动，因此需要替代品。此外，对于重小牛肉（体重（100公斤）），已经描述了葡萄糖稳态和胰岛素敏感性的问题（即高血糖和高胰岛素血症的高发生率），用其他饮食底物替代乳糖在经济上具有吸引力，并且也可能具有积极意义。 （或负面影响）发生葡萄糖代谢问题的风险。设计了一个实验来研究用葡萄糖，果糖或甘油替代饮食中的三分之一的乳糖对小牛的葡萄糖稳态和胰岛素敏感性的影响。 -向弗里斯兰（体重= 114±2.4公斤;年龄= 97±1.4 d）小牛喂食MR，其MR含462 g乳糖/ kg（CON），或其中MR被150 g乳糖/ kg MR代替葡萄糖（GLU），果糖（FRU）或甘油（GLY）在试验的前10天中，所有小牛都接受了CON，CON组继续采用这种饮食，其他组接​​受了8个月的实验饮食wk。测量在试验的第一个（基线）和最后一周进行。进行了频繁采样的静脉葡萄糖耐量测试以评估胰岛素敏感性，并收集了24小时尿液来测量葡萄糖排泄。在试验的最后一周，将1.5克[U-〜（13）C]底物推注到各自的餐食中，并测量血浆葡萄糖，胰岛素和〜（13）C-葡萄糖的响应。在试验开始时，胰岛素敏感性较低，并且仍较低[1.2±0.1和1.0±0.1（mU / L）〜（-1）×min〜（-1）]，并且未观察到治疗效果。试验开始时的葡萄糖排泄量低（3.4±1.0 g / d），但CON和GLU犊牛（26.9±3.9和43.0±10.6 g / d）增加，而FRU和GLY犊牛则没有。与CON犊牛相比，餐后葡萄糖的GLU较高，FRU较低，GLY相似。与CON犊牛相比，FRU和GLY的餐后胰岛素水平较低，而GLU的餐后胰岛素水平较低。餐后〜（13）C-葡萄糖在FRU和GLY小牛中显着增加，表明小牛能够将这些底物部分转化为葡萄糖。我们得出的结论是，用MR中的葡萄糖，果糖或甘油替代MR中的乳糖的三分之一会差异地影响餐后葡萄糖的体内稳态，但不会影响小牛的胰岛素敏感性。

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  • 来源
    《Journal of dairy science》 |2016年第4期|3072-3080|共9页
  • 作者

    A. J. Pantophlet; M. S. Gilbert; J. J. G. C. van den Borne; W. J. J. Gerrits; H. Roelofsen; M. G. Priebe; R. J. Vonk;

  • 作者单位

    Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands;

    Animal Nutrition Group, Wageningen University, PO Box 338, 6700 AH Wageningen, the Netherlands;

    Animal Nutrition Group, Wageningen University, PO Box 338, 6700 AH Wageningen, the Netherlands;

    Animal Nutrition Group, Wageningen University, PO Box 338, 6700 AH Wageningen, the Netherlands;

    Medical Biomics, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands;

    Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands;

    Medical Biomics, University Medical Centre Groningen, PO Box 30001, 9700 RB Groningen, the Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    veal calves; fructose; glycerol; insulin sensitivity; glucose homeostasis;

    机译：小牛犊果糖;甘油胰岛素敏感性葡萄糖稳态;

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