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首页> 外文期刊>Journal of dairy science >Periparturient dairy cows do not exhibit hepatic insulin resistance, yet adipose-specific insulin resistance occurs in cows prone to high weight loss
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Periparturient dairy cows do not exhibit hepatic insulin resistance, yet adipose-specific insulin resistance occurs in cows prone to high weight loss

机译：围产期奶牛不表现出肝脏胰岛素抵抗，但在容易出现高体重减轻的母牛中出现脂肪特异性胰岛素抵抗

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摘要

The periparturient period in dairy cows is associated with alterations in insulin action in peripheral tissues; however, the molecular mechanism underlying this process is not completely understood. The objective was to examine the response to a glucose tolerance test (GTT) and to analyze insulin signaling in liver and adipose tissues in pre- and postpartum dairy cows. Liver and adipose tissue biopsies were taken before and after GTT, at 17 d prepartum and again at 3 to 5 d postpartum from 8 high-yielding Israeli Holstein dairy cows. Glucose clearance rate after GTT was similar pre- and postpartum. Basal insulin concentrations and the insulin response to GTT were approximately 4-fold higher prepartum than postpartum. In accordance, phosphor-ylation of the hepatic insulin receptor after GTT was higher prepartum than postpartum. Across periods, a positive correlation was observed between the basal and peak plasma insulin and phosphorylated insulin receptor after GTT in the liver. Hepatic phosphorylation of protein kinase B after GTT was elevated pre- and postpartum. Conversely, in adipose tissue, phosphorylation of protein kinase B after GTT pre- and postpartum was increased only in 4 out of 8 cows that lost less body weight postpartum. Our results demonstrate that hepatic insulin signaling is regulated by plasma insulin concentrations as part of the homeorhetic adjustments toward calving, and do not support a model of hepatic insulin resistance in periparturient cows. Nevertheless, we suggest that specific insulin resistance in adipose tissue occurs pre- and postpartum only in cows prone to high weight loss. The different responses among these cows imply that genetic background may affect insulin responsiveness in adipose tissue pre- and postpartum.
机译：奶牛围产期与周围组织中胰岛素作用的改变有关。但是，这个过程的分子机制尚不完全清楚。目的是检查对葡萄糖耐量测试（GTT）的反应，并分析产前和产后奶牛肝脏和脂肪组织中的胰岛素信号传导。在GTT之前和之后，在产前17天和产后3到5天，对8头高产以色列荷斯坦奶牛进行了肝和脂肪组织活检。产前和产后GTT后的葡萄糖清除率相似。产前基础胰岛素浓度和对GTT的胰岛素反应比产后高约4倍。因此，GTT后肝胰岛素受体的磷酸化水平高于产后。在整个时期中，肝脏中GTT后的基础和峰值血浆胰岛素与磷酸化胰岛素受体之间均存在正相关。产前和产后GTT后蛋白激酶B的肝磷酸化水平升高。相反，在脂肪组织中，GTT产前和产后蛋白质激酶B的磷酸化仅在8头产后体重减轻的母牛中增加了4头。我们的结果表明，肝脏胰岛素信号传导受血浆胰岛素浓度的调节，作为产犊顺势调整的一部分，并不支持围产期母牛的肝脏胰岛素抵抗模型。尽管如此，我们建议脂肪组织中的特定胰岛素抵抗仅在容易出现高体重减轻的母牛产前和产后发生。这些母牛之间的不同反应表明，遗传背景可能会影响产前和产后脂肪组织中的胰岛素反应性。

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  • 来源
    《Journal of dairy science》 |2013年第9期|5656-5669|共14页
  • 作者

    M. Zachut; H. Honig; S. Striem; Y. Zick; S. Boura-Halfon; U. Moallem;

  • 作者单位

    Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, PO Box 6, Bet-Dagan, 50250, Israel,Department of Animal Science, the Robert H. Smith Faculty of Agriculture, Food and Environmental Quality Sciences, the Hebrew University of Jerusalem, Rehovot, 76100, Israel;

    Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, PO Box 6, Bet-Dagan, 50250, Israel;

    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel;

    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel;

    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel;

    Department of Ruminant Science, Institute of Animal Sciences, Volcani Center, PO Box 6, Bet-Dagan, 50250, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    peripartum insulin resistance; insulin receptor; protein kinase B (Akt);

    机译：围产期胰岛素抵抗胰岛素受体蛋白激酶B（Akt）;

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